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Biomedical subjects

Karl Holubar

Publications and source records attributed to Karl Holubar.

At least 19 recordsLinked to original sources

Two patients.

Explore the source record for details and available documents.

Dermatology↗

The compilation and edition of the first color atlas of dermatology by Robert Willan (1757-1812), Thomas Bateman (1778-1821), and Ashby Smith (?-1831) from 1790 to 1817.

An account is given of the development of early dermatologic iconography, mostly in watercolors and copper prints, as a consequence of late Enlightenment perspectives and the development of a visually-dependent concept in a text-dominated discipline of dermatology. The first great atlases in the field of dermatology by Robert Willan (1757-1812) and Jean-Louis Alibert (1768-1837), and by M. N. Devergie (1784-1842) in venereology, are addressed and Willan's work is elaborated in detail.

Anatomy, Artistic↗

History and clinical significance of mechanical symptoms in blistering dermatoses: a reappraisal.

In the era before the advent of routine microscopy and immunopathology, mechanical symptoms were described in an attempt to facilitate clinical diagnosis of blistering dermatoses. A plethora of eponyms and signs were described, but no proper original quotations exist. All the eponyms haunt the student and specialist. In the case of an ominous and, therefore, very important clinical phenomenon termed the Nikolskiy sign, this creates confusion about the specific meaning of the term, obscuring diagnosis and delaying initiation of an adequate treatment of pemphigus. We try to set this record straight and go to the sources. Russian, German, French, and English, at the least, are required to properly interpret the relevant descriptions. We provide an accurate interpretation of the major mechanical symptoms pathognomonic for acantholysis, dermoepidermal separation, and peeling of the entire epidermis. Correct performance of the tests and proper interpretation of the results can serve as an invaluable diagnostic tool to assist in the preliminary bedside diagnosis of serious and potentially lethal bullous dermatoses.

Europe↗