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Biomedical subjects

Karl Ludwig

Publications and source records attributed to Karl Ludwig.

12 recordsLinked to original sources
PubMed2005

Osteoid osteoma in an ex vivo animal model: temperature changes in surrounding soft tissue during CT-guided radiofrequency ablation.

PURPOSE: To assess temperature changes in the soft tissue surrounding bone during radiofrequency (RF) ablation of osteoid osteoma in an ex vivo animal model. MATERIALS AND METHODS: Intracortical cavities were created in fresh bovine long bone specimens obtained from a slaughterhouse as models for osteoid osteoma. Three groups of three specimens each were defined according to the thickness (1, 3, and 5 mm) of the cortical bone lamella separating the nidus from the periosteum. Three thermocouples were applied to the soft tissue surrounding the bone in defined distances (0, 5, and 10 mm) from the periosteum. Before RF ablation, the thickness of the cortical bone lamella was documented at computed tomography. Specimens were heated in a 37 degrees C basin. As soon as the measured temperature in the cavity of the specimen reached 35 degrees C, RF ablation was performed for 400 seconds, with a target temperature of 95 degrees C. During RF ablation, continuous measurements were performed simultaneously with digital thermometers. No simulation of vessel perfusion was used. The effect of the thickness of residual osseous lamella and the effect of the distance between the thermocouple and the periosteum were tested with an analysis of variance. Post hoc Bonferroni tests were performed. RESULTS: Mean maximum temperatures of 69.1 degrees, 51.3 degrees, and 42.5 degrees C for 1-mm lamella; 59.2 degrees, 46.5 degrees, and 41.1 degrees C for 3-mm lamella; and 50.6 degrees, 44.8 degrees, and 40.0 degrees C for 5-mm lamella were measured 0, 5, and 10 mm, respectively, from the periosteum. Significant temperature differences were shown with analysis of variance and post hoc tests for the three groups of bone lamella thickness and distance (P < .001). CONCLUSION: In the model of osteoid osteoma, the surrounding temperature (soft tissue) during RF ablation was shown to depend on the thickness of the cortical bone lamella and the distance from the periosteum.

Analysis of Variance↗
PubMed2004

Reconstruction of the pelvic ring using an autologous free non-vascularized fibula graft in a patient with benign fibrous histiocytoma.

BACKGROUND: Benign fibrous histiocytomas (BFH) usually presents as a small benign lesion that predominantly occurs in the skin. Only few cases of BFH arising from bone have been reported, its occurrence in pelvic bones is even rarer. CASE PRESENTATION: A 34-year-old female presented with BFH at a rare anatomical location on both sides of the os ilium which was larger than earlier reported BFH of the bone. Surgical resection was performed successfully including resection of the inner pelvic ring and reconstruction of the linea terminalis using a non-vascularized fibular autograft. At 18 months after tumor resection and reconstruction of the pelvic ring, with interposition of a free vascularized fibula graft patient has an excellent clinical oncological and functional outcome. CONCLUSION: Non vascularized fibular autograft is a useful reconstructive procedure in select patients.

Journal Article↗
PubMed2004

Detection of pulmonary nodules at multirow-detector CT: effectiveness of double reading to improve sensitivity at standard-dose and low-dose chest CT.

The purpose of this study was to assess the effectiveness of double reading to increase the sensitivity of lung nodule detection at standard-dose (SDCT) and low-dose multirow-detector CT (LDCT). SDCT (100 mAs effective tube current) and LDCT (20 mAs) of nine patients with pulmonary metastases were obtained within 5 min using four-row detector CT. Softcopy images reconstructed with 5-mm slice thickness were read by three radiologists independently. Images with 1.25-mm slice thickness served as the gold standard. Sensitivity was assessed for single readers and combinations. The effectiveness of double reading was expressed as the increase of sensitivity. Average sensitivity for detection of 390 nodules (size 3.9+/-3.2 mm) for single readers was 0.63 (SDCT) and 0.64 (LDCT). Double reading significantly increased sensitivity to 0.74 and 0.79, respectively. No significant difference between sensitivity at SDCT and LDCT was observed. The percentage of nodules detected by all three readers concordantly was 52% for SDCT and 47% for LDCT. Although double reading increased the detection rate of pulmonary nodules from 63% to 74-79%, a considerable proportion of nodules remained undetected. No difference between sensitivities at LDCT and SDCT for detection of small nodules was observed.

Adult↗
PubMed2004

Low-voltage digital selenium radiography: detection of simulated interstitial lung disease, nodules, and catheters--a phantom study.

PURPOSE: To compare three tube voltages in digital selenium radiography for the detection of simulated interstitial lung disease, nodules, and catheters. MATERIALS AND METHODS: Simulated catheters, nodules, and ground-glass, linear, miliary, and reticular patterns were superimposed over an anthropomorphic chest phantom. Digital selenium radiography was performed with different tube voltages (70, 90, and 150 kVp). Hard-copy images were generated. Detection performance of five radiologists was compared by using receiver operating characteristic (ROC) analysis involving 54,000 observations. RESULTS: The detection of ground-glass, linear, miliary, and reticular patterns over lucent lung and of nodules equal to, smaller than, and larger than 10 mm increased when 70 kVp and/or 90 kVp was used. However, only the reticular pattern was significantly better detected at lower peak voltage (P <.05). Simulated catheters and nodules over the mediastinum showed smaller areas under the ROC curve at lower peak voltage. These results were not statistically significant (P >.05). CONCLUSION: The diagnostic performance of digital selenium radiography at lower peak voltage is at least as good as that at higher peak voltage for interstitial lung disease over lucent lung. Performance is equivalent for nodules and catheters over obscured chest regions at lower peak voltages compared with that at 150 kVp. Our results implicate that the use of high-voltage technique in digital selenium radiography should be reassessed.

Catheterization↗
PubMed2004

Diagnostic performance of a flat-panel detector at low tube voltage in chest radiography: a phantom study.

RATIONALE AND OBJECTIVES: To evaluate a large area, cesium iodide amorphous silicon flat-panel detector (CsI/a-Si) at 3 tube voltages to detect simulated interstitial lung disease, nodules, and catheters. METHODS: Simulated interstitial lung disease, nodules, and catheters were superimposed over a chest phantom. Images were generated at 125 kVp, 90 kVp, and 70 kVp at the same surface dose and reduced effective dose equivalent for 90 kVp and 70 kVp and printed on hard copies. Fifty-four thousand observations were analyzed by receiver operating characteristic (ROC). RESULTS: Detectability of linear, miliary, reticular pattern, and nodules over lucent lung as well as of catheters and nodules over obscured chest areas increased at 90 and/or 70 kVp with higher Az values; however, only it was statistically significant for reticular pattern at 70 kVp and nodules at 90 kVp compared with 125 kVp (P < 0.05). The detection of ground-glass pattern was worse at lower kVp (P > 0.05). CONCLUSION: For most simulated patterns, differences in diagnostic performance at 70 kVp/90 kVp and 125 kVp were not significant, except for reticular pattern and nodules over lucent lung.

Cesium↗
PubMed2003

Lumbar spine radiography: digital flat-panel detector versus screen-film and storage-phosphor systems in monkeys as a pediatric model.

PURPOSE: To assess image quality and exposure dose requirements of a flat-panel detector system versus screen-film and storage-phosphor systems for radiographic depiction of the lumbar spine in Cynomolgus monkeys as a pediatric model. MATERIALS AND METHODS: Twenty Cynomolgus monkeys underwent anteroposterior radiography of the lumbar spine. The size and weight of these monkeys are comparable to those of infants 3-4 months of age. Images were acquired with speed class 400 screen-film, flat-panel, and storage-phosphor systems with identical exposure dose. All other conditions were matched exactly. Additional images were acquired with the flat-panel and storage-phosphor systems at exposure doses equivalent to speed classes 800 and 1600. All images were obtained at 66 kVp without antiscatter grid. Images were assessed independently by three radiologists for visibility of 60 anatomic structures by using a five-point confidence scale. Scores were calculated for the seven combinations of imaging mode and exposure dose and were compared by using the Friedman test. RESULTS: Scores were 1.70 (speed class 400), 1.97 (speed class 800), and 2.27 (speed class 1600) for the flat-panel system; 2.50 (speed class 400) for the screen-film system; and 2.58 (speed class 400), 2.77 (speed class 800), and 3.13 (speed class 1600) for the storage-phosphor system. Scores for the flat-panel system at speed classes 400 and 800 were significantly lower (indicating better visibility) than those of the screen-film and storage-phosphor systems (P <.05). CONCLUSION: The flat-panel system is superior to screen-film and storage-phosphor systems in lumbar spine radiography in monkeys. With the flat-panel system, exposure dose can be reduced by 75% without loss in image quality.

Animals↗
PubMed2003

Detection of subtle undisplaced rib fractures in a porcine model: radiation dose requirement--digital flat-panel versus screen-film and storage-phosphor systems.

PURPOSE: To compare a large-area direct read-out flat-panel detector radiography system with screen-film and storage-phosphor systems with regard to detection of subtle undisplaced rib fractures and to assess the diagnostic performance of the flat-panel system with decreasing exposure level. MATERIALS AND METHODS: Subtle fractures were created artificially in 100 of 200 porcine rib specimens. Specimens were enclosed in containers of water to generate absorption and scatter radiation conditions similar to those of a human chest wall. Imaging was performed with flat-panel, screen-film, and storage-phosphor systems with conditions that were exactly matched. Different exposure levels equivalent to speed classes (S) of 400, 800, 1,600, and 6,400 were used. All images were independently assessed for the presence of fracture by three radiologists with a five-level confidence scale. Receiver operating characteristic (ROC) analysis was performed for a total of 4,200 observations (600 for each imaging system and exposure level). Diagnostic performance was estimated with area under the ROC curve (Az). Significance of differences in diagnostic performance was tested with analysis of variance. RESULTS: ROC analysis yielded mean Az values for the flat-panel system of 0.879 (S = 400), 0.833 (S = 800), 0.765 (S = 1,600), and 0.576 (S = 6,400). Az values were 0.834 (S = 400) for the screen-film system and 0.789 (S = 400) and 0.729 (S = 800) for the storage-phosphor system. Analysis of variance revealed significant differences in diagnostic performance between various combinations of imaging system and exposure levels (P <.05). CONCLUSION: The flat-panel system is superior to the screen-film and storage-phosphor systems for detection of subtle undisplaced rib fractures at clinical exposure settings (eg, S = 400). With the flat-panel system, radiation dose can be reduced by 50% to achieve diagnostic performance comparable to that of a speed class 400 screen-film system.

Animals↗
PubMed2003

CT colonography: Protocol optimization with multi-detector row CT--study in an anthropomorphic colon phantom.

PURPOSE: To determine optimal detector collimation, section thickness, and tube current for multi-detector row computed tomography (CT) colonography. MATERIALS AND METHODS: An anthropomorphic colon phantom with simulated polyps of varying size (2, 6, 8, 10, and 12 mm) was examined by using multi-detector row CT with varying combinations of detector collimation (4 x 1.0 mm and 4 x 2.5 mm), dose per section (10, 20, 40, 60, 80, 100, and 140 mAs), and section thickness/reconstruction interval (1.25/0.6, 2.0/1.0, 3.0/1.0, and 5.0/2.0 mm). Polyp depiction, longitudinal polyp distortion, and presence of rippling artifacts were assessed on reformatted three-dimensional endoluminal images by three reviewers. RESULTS: Longitudinal distortion and rippling artifacts increased with increasing section thickness and use of broader detector collimation. Polyps 8 mm or larger were depicted with any combination of section thickness, detector collimation, and tube current. Depiction of polyps 6 mm or smaller depended on the detector collimation/reconstructed section thickness and was rated optimal for the 4 x 1.0-mm detector collimation with a section thickness of 1.25 mm. This was also observed for low-dose protocols. Polyps 6 mm or smaller that were not detected with 3-mm section thickness and 4 x 2.5-mm detector collimation were detected with 1.25-mm section thickness and 10 mAs. CONCLUSION: A narrow detector collimation with thin-section imaging (4 x 1.0-mm detector collimation, 1.25-mm section thickness) is a prerequisite for low-dose (10-mAs) multi-detector row CT colonography.

Artifacts↗
PubMed2002

Performance of a flat-panel detector in the detection of artificial erosive changes: comparison with conventional screen-film and storage-phosphor radiography.

The purpose of this study was to compare a large-area, direct-readout, flat-panel detector system with a conventional screen-film system, a storage-phosphor system, and a mammography screen-film system with regard to the detection of artificial bone erosions simulating rheumatoid disease, and to assess its diagnostic performance with decreasing exposure dose. Six hundred forty regions were defined in 160 metacarpophalangeal and proximal interphalangeal joint specimens from 20 monkey paws (4 regions per joint). Artificial bone erosions were created in 320 of these 640 regions. Specimens were enclosed in containers filled with water to obtain absorption and scatter radiation conditions similar to those of a human hand. Imaging was performed using a flat-panel system, a speed class 200 screen-film system, a mammography screen-film system, and a storage-phosphor system under exactly matched conditions. Different exposure doses equivalent to speed classes of S=100, 200, 400, 800, 1600, and 3200 were used. In all images the presence or absence of a lesion was assessed by three radiologists using a five-level confidence scale. Receiver operating characteristic (ROC) analysis was performed for a total of 21,120 observations (1920 for each imaging modality and exposure level) and diagnostic performance estimated by the area under the ROC curve (A(z)). The significance of differences in diagnostic performance was tested with analysis of variance. The ROC analysis showed A(z) values of 0.809 (S=200), 0.768 (S=400), 0.737 (S=800), 0.710 (S=1600), and 0.685 (S=3200) for the flat-panel system, 0.770 for the speed class 200 screen-film system, 0.781 (S=200), 0.739 (S=400), 0.724 (S=800), 0.680 (S=1600) for the storage-phosphor system, and 0.798 for the mammography screen-film system. Analysis of variance showed significant differences between different combinations of imaging modalities and exposure doses ( p<0.05). The diagnostic performance of the flat-panel detector system is superior to that of a screen-film system and a storage-phosphor system for the detection of erosive lesions at clinical exposure settings (S=200). Using the flat-panel system the exposure dose can be reduced by 50% to obtain a diagnostic performance comparable to a speed class 200 screen-film system.

Animals↗
PubMed2002

Performance of a flat-panel detector in detecting artificial bone lesions: comparison with conventional screen-film and storage-phosphor radiography.

PURPOSE: To compare a large-area direct-readout flat-panel detector system with a conventional screen-film system and a storage-phosphor system in detecting small artificial osseous lesions simulating osteolytic disease and to assess diagnostic performance with decreasing exposure dose. MATERIALS AND METHODS: Artificial lesions (0.5-3.0 mm) were created in 100 of 200 predefined regions in 20 porcine femoral specimens. Specimens were enclosed in containers filled with water to create absorption and scatter radiation conditions comparable with those in a human extremity. Imaging was performed with a flat-panel detector system, a conventional screen-film system, and a storage-phosphor system. Levels of exposure equivalent to speed classes 400, 800, 1600, and 3200 were used. In all images, the presence or absence of a lesion was assessed by three radiologists using a five-point confidence scale. Receiver operating characteristic (ROC) analysis was performed for 4,800 observations (600 for each imaging modality and exposure level) and diagnostic performance estimated with the area under the ROC curve (A(z)). The significance of differences in diagnostic performance was tested with analysis of variance. RESULTS: ROC analysis showed A(z) values of 0.820 (speed class 400), 0.780 (class 800), 0.758 (class 1600), and 0.676 (class 3200) for the flat-panel detector; 0.761 (class 400), 0.725 (class 800), and 0.662 (class 1600) for the storage-phosphor system; and 0.788 (class 400) for the conventional screen-film system. The A(z) value for the flat-panel detector at speed class 400 was significantly higher than that for all other systems (P <.05). A(z) values for the speed class 400 screen-film system and flat-panel detector system at speed class 800 were not significantly different. CONCLUSION: The flat-panel detector has diagnostic performance superior to that of conventional screen-film and storage-phosphor radiography for detecting small artificial osseous lesions at clinical exposure settings. With the flat-panel detector, exposure dose can be reduced by 50% to obtain diagnostic performance comparable with that of a conventional speed class 400 screen-film system.

Animals↗
PubMedDate not supplied

Injuries and overuse syndromes in golf.

BACKGROUND: Although golf is becoming more popular, there is a lack of reliable epidemiologic data on golf injuries and overuse syndromes, especially regarding their severity. OBJECTIVE: To perform an epidemiologic study of the variety of different musculoskeletal problems in professional and amateur golfers and to find associations of age, sex, physical stature (body mass index), warm-up routine, and playing level with the occurrence of reported injuries. STUDY DESIGN: Retrospective cohort study. METHODS: We analyzed the injury data from a total of 703 golfers who were randomly selected over two golfing seasons and interviewed with the use of a six-page questionnaire. RESULTS: Overall, 82.6% (N = 526) of reported injuries involved overuse and 17.4% (N = 111) were single trauma events. Professional golfers were injured more often, typically in the back, wrist, and shoulder. Amateurs reported many elbow, back, and shoulder injuries. Severity of reported injuries was minor in 51.5%, moderate in 26.8%, and major in 21.7% of cases. Carrying one's bag proved to be hazardous to the lower back, shoulder, and ankle. Warm-up routines were found to have a positive effect if they were at least 10 minutes long. CONCLUSIONS: Overall, golf may be considered a rather benign activity, if overuse can be avoided. If not, golf can result in serious, chronic musculoskeletal problems.

Adult↗