Biomedical subjects

Katarina Sjögreen

Publications and source records attributed to Katarina Sjögreen.

5 recordsLinked to original sources

PubMed2005

A new method to obtain transmission images for planar whole-body activity quantification.

UNLABELLED: Dosimetry is important in the evaluation of new radiopharmaceuticals and in radionuclide therapy treatment planning. The base is an accurate in vivo measurement of the spatial and temporal distribution of the administered radioactivity. This can be made by planar whole-body activity quantification using the conjugate-view method where a geometrical-mean image is corrected for attenuation by a measured transmission image. We present a new method to measure whole-body transmission images using the X-ray unit on a single photon emission computed tomography/computed tomography (SPECT/CT) scintillation system. METHOD: Two general problems are associated with this method: (1) the divergence of the X-ray beam and (2) the scaling of the resulting image. We have applied linear transformations and scale by a system-generated factor to obtain images corresponding to a radiological depth at 70 keV. We validated the method by measurements of the radiological depth for different types of phantoms, and in terms of activity quantification accuracy when applying the method for attenuation correction. RESULTS: An accuracy of within +/-4% was found for both the radiological depth measurements and for the activity-quantification measurements. CONCLUSIONS: The advantage with the proposed method is that it is fast (2 minutes for a 2-minute scan), it has good spatial resolution and signal-to-noise ratio, and it is easy to carry out for the patient.

Humans↗

PubMed2005

The LundADose method for planar image activity quantification and absorbed-dose assessment in radionuclide therapy.

A new method for absorbed-dose assessment in radionuclide therapy is presented in this paper. The method is based on activity quantification by the conjugate-view methodology, applied to serial whole-body, anterior-posterior, scintillation-camera scans. The quantification method is an extension of previous studies, and includes separate corrections for attenuation, scatter, and overlapping organs. Further development has now been undertaken to take into account the capabilities of new dual-head camera systems with a built-in X-ray tube for anatomical imaging. Furthermore, the modeling of time-activity data is included, and dosimetric calculations based on the formalism by the Medical Internal Radiation Dose (MIRD) committee. To streamline absorbed-dose assessments for a large number of patient studies, the programs for quantification, image registration, and absorbed-dose calculations have been embedded in an envelop program termed LundADose, where calculations, to a great extent, are performed automatically. Evaluation of the whole-body activity quantification is performed for patients undergoing radioimmunotherapy by monoclonal antibodies labeled with (111)In or (90)Y.

Cobalt Radioisotopes↗

PubMed2003

3D absorbed dose calculations based on SPECT: evaluation for 111-In/90-Y therapy using Monte Carlo simulations.

A general method is presented for patient-specific three-dimensional (3D) absorbed dose calculations based on quantitative SPECT activity measurements. The computational scheme includes a method for registration of the CT study to the SPECT image, and compensation for attenuation, scatter, and collimator-detector response including septal penetration, performed as part of an iterative reconstruction method. From SPECT images, the absorbed dose rate is calculated using an EGS4 Monte Carlo code, which converts the activity distribution to an absorbed dose rate distribution. Evaluation of the accuracy in the activity quantification and the absorbed dose calculation is based on realistic Monte Carlo simulated SPECT data of a voxel-computer phantom and (111)In and (90)Y. Septal penetration was not included in this study. The SPECT-based activity concentrations and absorbed dose distributions are compared to the actual values; the results imply that the corrections for attenuation and scatter yield results of high accuracy. The presented method includes compensation for most parameters deteriorating the quantitative image information. Inaccuracies are, however, introduced by the limited spatial resolution of the SPECT system, which are not fully compensated by the collimator-response correction. The proposed evaluation methodology may be used as a basis for future inter-comparison of different dosimetry calculation schemes.

Humans↗

PubMed2002

An activity quantification method based on registration of CT and whole-body scintillation camera images, with application to 131I.

UNLABELLED: This article presents a new method for conjugate view activity quantification for 131I-labeled monoclonal antibody distribution. METHODS: The method is based on the combined use of images from 3 modalities: whole-body (WB) scintillation camera scanning, WB transmission scanning using 57Co, and CT. All images are coaligned using a recently developed program for the registration of WB images. Corrections for attenuation, scatter, and septal penetration are performed in image space. Compensation for scatter and septal penetration is performed by deconvolution, using point-response functions determined from Monte Carlo simulations. Attenuation correction is performed by applying a patient-specific 364-keV narrow-beam attenuation map obtained by combining information from the CT and the transmission scan. A relationship is presented for the conversion of the CT numbers to mass density. The attenuation- and scatter-compensated image is converted from counts to activity using a sensitivity value that was determined for 364-keV photons in air. This activity projection image is then analyzed for the activity of volumes of interest (VOI) using 2-dimensional regions of interest (ROIs) that are determined from the CT study. The CT is first resliced into coronal slices, and a maximum-extension ROI is outlined that encloses the VOI. Compensation for background activity and overlapping organs is performed on the basis of total patient thickness in the projection line, and on precalculated organ- background thickness fractions. RESULTS: Method evaluation was performed using data from both experimental measurements and Monte Carlo simulations. The use of an attenuation map derived directly from the CT study was also evaluated. For organ activity quantification, an accuracy of > or =10% was obtained. For small-diameter tumors, deviations were larger because of lack of correction for the background-dependent partial-volume effect. CONCLUSION: Registration of CT and WB scintillation camera images was successfully applied to improve activity quantification by the conjugate view method.

Antibodies, Monoclonal↗

PubMed2002

A 3-dimensional absorbed dose calculation method based on quantitative SPECT for radionuclide therapy: evaluation for (131)I using monte carlo simulation.

UNLABELLED: A general method is presented for patient-specific 3-dimensional absorbed dose calculations based on quantitative SPECT activity measurements. METHODS: The computational scheme includes a method for registration of the CT image to the SPECT image and position-dependent compensation for attenuation, scatter, and collimator detector response performed as part of an iterative reconstruction method. A method for conversion of the measured activity distribution to a 3-dimensional absorbed dose distribution, based on the EGS4 (electron-gamma shower, version 4) Monte Carlo code, is also included. The accuracy of the activity quantification and the absorbed dose calculation is evaluated on the basis of realistic Monte Carlo-simulated SPECT data, using the SIMIND (simulation of imaging nuclear detectors) program and a voxel-based computer phantom. CT images are obtained from the computer phantom, and realistic patient movements are added relative to the SPECT image. The SPECT-based activity concentration and absorbed dose distributions are compared with the true ones. RESULTS: Correction could be made for object scatter, photon attenuation, and scatter penetration in the collimator. However, inaccuracies were imposed by the limited spatial resolution of the SPECT system, for which the collimator response correction did not fully compensate. CONCLUSION: The presented method includes compensation for most parameters degrading the quantitative image information. The compensation methods are based on physical models and therefore are generally applicable to other radionuclides. The proposed evaluation methodology may be used as a basis for future intercomparison of different methods.

Humans↗