Biomedical subjects

Kate E Nichols

Publications and source records attributed to Kate E Nichols.

4 recordsLinked to original sources

PubMed2005

Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood.

Gene-environment interactions are presumed to shape human behavior during early development. However, no human research has demonstrated that such interactions lead to stable individual differences in fear responses. We tested this possibility by focusing on a polymorphism in the promoter region of the gene for the serotonin transporter (5-HTT). This polymorphism has been linked to many indices of serotonin activity. Specifically, we tested the hypothesis that an interaction between children's 5-HTT status and maternal reports of social support predicts inhibited behavior with unfamiliar peers in middle childhood. Results were consistent with this hypothesis: Children with the combination of the short 5-HTT allele and low social support had increased risk for behavioral inhibition in middle childhood.

Child↗

PubMed2005

Behavioral inhibition: linking biology and behavior within a developmental framework.

Behavioral inhibition refers to a temperament or style of reacting that some infants and young children exhibit when confronted with novel situations or unfamiliar adults or peers. Research on behavioral inhibition has examined the link between this set of behaviors to the neural systems involved in the experience and expression of fear. There are strong parallels between the physiology of behaviorally inhibited children and the activation of physiological systems associated with conditioned and unconditioned fear. Research has examined which caregiving behaviors support the frequency of behavioral inhibition across development, and work on the interface of cognitive processes and behavioral inhibition reveal both how certain cognitive processes moderate behavioral inhibition and how this temperament affects the development of cognition. This research has taken place within a context of the possibility that stable behavioral inhibition may be a risk factor for psychopathology, particularly anxiety disorders in older children. The current chapter reviews these areas of research and provides an integrative account of the broad impact of behavioral inhibition research.

Affect↗

PubMed2003

Maternal power assertion in discipline and moral discourse contexts: commonalities, differences, and implications for children's moral conduct and cognition.

Parental power assertion is traditionally studied in the behavioral domain--discipline triggered by the child's immediate misbehavior--but rarely in the cognitive domain--parent-child discussions of the child's past misbehavior. Maternal power assertion was observed in "do" and 'don't" discipline contexts from 14 to 45 months and in the context of mother-child discourse about a recent misbehavior at 56 months. Mothers' use of power cohered across the "do," 'don't," and discourse contexts, but its implications were domain specific. Power assertion in the 'don't" discipline context predicted behavioral outcomes (more moral conduct at 56 and 73 months, less antisocial conduct at 73 months) but not cognitive outcomes (moral cognition at 56 and 73 months). Power assertion in the discourse context predicted less mature moral cognition but not moral or antisocial conduct. Mothers' high Neuroticism predicted more power assertion in all three contexts. Child effects were examined.

Adult↗

PubMedDate not supplied

Guilt in young children: development, determinants, and relations with a broader system of standards.

In this comprehensive study of the early development of guilt, 106 children were observed in laboratory paradigms in which they were led to believe that they had damaged valuable objects, during two separate sessions at each of the assessments at 22, 33, and 45 months. The behavioral and affective components of guilt cohered significantly across the sessions, converged with each other, were stable across all the assessments, and corresponded modestly with maternal reports. Most components decreased with age, except for bodily tension, which increased. At 33 and 45 months, girls displayed more guilt than did boys. Children who were more fearful in typical fear-inducing paradigms also displayed more guilt. Children of mothers who relied on more power-assertive discipline, observed and self-reported, displayed less guilt. Guilt related positively to the development of self at 18 months and to moral self at 56 months. Children who displayed more guilt were less likely to violate rules of conduct at 56 months. A mediational model was supported: Fearful temperament contributed to guilt proneness, which in turn served to inhibit children's tendency to violate rules.

Affect↗