Helaman Ferguson profile. Carving his own unique niche, in symbols and stone.
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News↗
Biomedical subjects
Katherine Unger
Publications and source records attributed to Katherine Unger.
Migration and Dispersal. Follow the footprints.
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Animal Identification Systems↗
Paleontology. Fossil embryos hint at early start for complex development.
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Animals↗
Scientific misconduct. Cleaning up the paper trail.
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Authorship↗
Scientific misconduct. Even retracted papers endure.
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Bibliometrics↗
U.S. higher education. Foreign grad students show renewed interest.
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Biological Science Disciplines↗
Blastic mantle cell lymphoma developing concurrently in a patient with chronic myelogenous leukemia and a review of the literature.
Non-Hodgkin's lymphoma (NHL) occurring as a synchronous malignancy with chronic myelogenous leukemia (CML) is rare. To our knowledge, this is the first case reported of a patient who developed mantle cell lymphoma (MCL) after therapy with imatinib mesylate for CML. After a 3-year history of CML, the patient developed a lymphocytosis associated with diarrhea, anorexia, and weight loss. Imaging studies revealed abdominal adenopathy and extensive lymphomatous infiltration of the liver, stomach, pancreas, and kidneys. Flow cytometric and cytogenetic studies were consistent with MCL. Fluorescence in situ hybridization (FISH) of the bone marrow revealed a genetically distinct lymphoid neoplasm rather than an extramedullary blast crisis of CML. The development of lung cancer, prostate cancer, CML and MCL in this patient suggests a genetic predisposition, although other factors, including environmental exposures and therapy with imatinib mesylate could have had a contributory or synergistic role in the development of MCL.
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