Are asthma sufferers at risk when consulting chiropractors over the Internet?
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Anti-Asthmatic Agents↗
Biomedical subjects
Katja Schmidt
Publications and source records attributed to Katja Schmidt.
Suppression of hepatitis B virus enhancer 1 and 2 by hepatitis C virus core protein.
BACKGROUND/AIMS: Epidemiological studies have shown that coinfection or superinfection with hepatitis B virus (HBV) and C virus (HCV) frequently leads to the suppression of hepatitis B virus replication. The mechanism of this phenomenon is still unclear. Shih et al. [J Virol 1993;67:5823] reported a direct suppression of HBV replication by the core protein of HCV. The target structure of HCV core protein in this system remained unclear. METHODS: As HCV core protein has been shown to influence expression from transcriptional elements, we studied whether HCV core protein altered the activity of the two HBV enhancers 1 and 2. Luciferase vectors for HBV enhancers 1 or 2 were cotransfected with expression constructs for HCV core protein in murine and human hepatocyte lines. RESULTS: Full-length HCV core protein suppressed the HBV enhancer 1 up to 11-fold, the enhancer 2 3-4-fold. Suppression of HBV enhancer 1 by HCV core from genotype 1b was stronger than by HCV core of genotypes 3a or 1a. Carboxyterminally truncated core proteins had lower or no suppression activity. CONCLUSIONS: These data suggest that HCV core protein may directly repress transcription of the HBV RNAs. This trans-repression may contribute to suppression of HBV replication in patients coinfected with both viruses.
Animals↗
Health risks over the Internet: advice offered by "medical herbalists" to a pregnant woman.
OBJECTIVES: The aim of this study was to investigate Internet advice offered by "medical herbalists" to a pregnant woman regarding herbal treatment of morning sickness. STUDY DESIGN: Search engines were used to find relevant Web sites and all potential e-mail addresses were contacted. Herbalists were asked for advice regarding three specific medicinal herbs: ginger, raspberry and juniper. RESULTS: Eighty-three e-mail addresses were found and contacted. The response rate was 51%. Nineteen (45%) of all respondents recommended ginger, 9 (21%) of them without mentioning adverse effects. Seven (17%) respondents recommended taking raspberry; five (12%) without mentioning adverse effects. No respondent recommended taking juniper during pregnancy and 12 herbalists (29%) warned about using this herbal remedy during pregnancy. CONCLUSIONS: Advice about herbal medicine is readily available over the Internet. The advice offered is misleading at best and dangerous at worst. Potential Internet users should be made aware of these problems and ways of minimizing the risk should be found.
Female↗