Kazuo Arai | PubMed Health

PubMed2002

X-ray diffractometer designed for industrial applications at SPring-8 BL24XU.

An X-ray diffractometer for industrial applications has been designed, installed at SPring-8 BL24XU and tested by measuring a standard Al(2)O(3) powder sample. The measurement results prove the high precision of the diffractometer. The diffractometer was also tested by conducting grazing-incidence X-ray diffraction measurements of ion-implanted chromium-coated steel. The validity of a new method for X-ray stress measurements of polished stainless steel is also proposed and confirmed. The results prove the suitability of this diffractometer for industrial applications.

Journal Article↗

PubMed2002

The presence of candidate tumor suppressor gene loci at chromosome 3p for oral squamous cell carcinomas.

We investigated the short arm of chromosome 3 (3p) for allelic imbalances, including loss of heterozygosity (LOH) and microsatellite instability (MSI) in 40 primary oral squamous cell carcinomas (SCCs) using 10 microsatellite markers and constructed a deletion map for this chromosome arm. We examined 40 primary tumor tissues, 40 corresponding normal tissues, and seven lymph node metastatic tissues. LOH at one or more loci was found in 24/40 (60%) of tumors. Deletion mapping of these tumors revealed at least three discrete, commonly deleted regions on the chromosome arm. Furthermore, we detected MSI in six of those tested cases (15%). We compared our results with the clinicopathologic features. A number of sites displaying LOH at 3p could be detected in early stage lesions, and the frequencies of LOH tended to be higher in later clinical stages. Thus, the frequent LOH was observed from early stage in pTNM classification. An unknown tumor suppressor gene in the genesis of oral squamous cell carcinoma may exist in 3p.

Adult↗