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Keerthilatha M Pai

Publications and source records attributed to Keerthilatha M Pai.

16 recordsLinked to original sources
PubMed2006

Principal component analysis and artificial neural network analysis of oral tissue fluorescence spectra: classification of normal premalignant and malignant pathological conditions.

Pulsed laser-induced autofluorescence spectroscopic studies of pathologically certified normal, premalignant, and malignant oral tissues were carried out at 325 nm excitation. The spectral analysis and classification for discrimination among normal, premalignant, and malignant conditions were performed using principal component analysis (PCA) and artificial neural network (ANN) separately on the same set of spectral data. In case of PCA, spectral residuals, Mahalanobis distance, and scores of factors were used for discrimination among normal, premalignant, and malignant cases. In ANN, parameters like mean, spectral residual, standard deviation, and total energy were used to train the network. The ANN used in this study is a classical multiplayer feed-forward type with a back-propagation algorithm for the training of the network. The specificity and sensitivity were determined in both classification schemes. In the case of PCA, they are 100 and 92.9%, respectively, whereas for ANN they are 100 and 96.5% for the data set considered.

Aged↗
PubMed2006

Discrimination of normal, inflammatory, premalignant, and malignant oral tissue: a Raman spectroscopy study.

Optical spectroscopy methods are fast emerging as potential alternatives for early diagnosis of cancer. A Raman spectroscopy method for discrimination of normal and malignant oral tissues has been developed by us earlier. It is necessary to evaluate and establish the validity of the approach before it can be routinely used. In the present study, our Raman spectroscopy investigations are extended further to evaluate the efficacy of the technique to discriminate between normal, inflammatory, premalignant, and malignant conditions in oral tissue. Spectral profiles of normal, malignant, premalignant, and inflammatory conditions show pronounced differences between one another. Spectra of normal tissues can be attributed mainly to lipids whereas pathological tissue spectra are dominated by proteins. Principal components analysis (PCA) of the spectral data sets belonging to the four different categories showed that scores of factors differentiated between normal and all pathological conditions but gave only poor discrimination among the three pathological states. PCA combined with multiparameter limit tests allow match/mismatch criteria to be applied to test samples when pathologically certified calibration sets are available in each class. It is shown that by this method all the four tissue types could be discriminated and diagnosed correctly. The biochemical differences between normal and pathological conditions of oral tissue are also discussed from spectral differences of the different classes of spectra.

Calibration↗
PubMed2006

Transmigration of impacted mandibular canines--report of 4 cases.

Impacted canines are not uncommon in clinical practice, but intraosseous movement of impacted canines crossing the midline (transmigration) is a rare phenomenon. We report 4 cases of mandibular canine transmigration to emphasize the need to supplement periapical radiographs with a panoramic radiographic examination in patients with over-retained deciduous canines or missing permanent canines.

Adult↗
PubMed2006

Multiple odontogenic keratocysts: report of a case.

Although odontogenic keratocysts are common in clinical practice, the simultaneous occurrence of multiple cysts in both the maxilla and mandible of a patient is rare. We report a case of an otherwise healthy individual who developed 17 cysts over 15 years.

Adult↗
PubMed2005

Noma: life cycle of a devastating sore - case report and literature review.

Noma (cancrum oris) is an orofacial gangrene, which during its fulminating course causes progressive and mutilating destruction of the infected tissues. The disease occurs mainly in children with malnutrition, poor oral hygiene and debilitating concurrent illness. Noma is well documented in the literature, but because most patients do not report to a doctor until the disease is at an advanced stage, its onset and progression remain a mystery. This case report, with a survey of recent relevant literature, highlights the different stages in the development of tissue necrosis, including onset and progression, with an emphasis on the need for early diagnosis and prompt treatment.

Bacteria, Anaerobic↗
PubMed2004

"Air bag" organoleptic behavioral experiment for managing fear of oral malodor.

People suffering from the fear of oral malodor believe that they have halitosis, even though offensive oral malodor is absent. Management of such patients is challenging. A simple innovative technique, "air bag" breathing method can be used as a behavioral experiment to provide the patient with evidence that may disconfirm their pertinent belief. In this method air samples are collected in an odor free plastic bag from the patient and healthy volunteers and the patient blindly rates the odor quality of each sample.

Behavior Therapy↗
PubMed2004

Papillon Lefevre syndrome.

Papillon-Lefevre syndrome is a very rare autosomal recessive condition characterised by pronounced palmoplantar hyperkeratosis and severe early onset periodontitis, leading to early loss of teeth. Here, we report a case of Papillon-Lefevre syndrome with a brief discussion on treatment aspect.

Adolescent↗
PubMed2004

Unusual post-extraction hemorrhage in a cardiac patient: a case report.

In patients with cyanotic congenital heart disease (CCHD), the need for antibiotic prophylaxis for infective endocarditis is well known among dentists, but not many dentists are aware of the associated hemorrhagic tendencies in such patients. We report a case of post-extraction hemorrhage in a patient with Eisenmenger's syndrome and discuss the importance of more elaborate hematologic evaluation in patients with CCHD before oral surgery.

Adult↗
PubMed2003

Cherubism in siblings: a case report.

Cherubism is a non-neoplastic bone disease characterized by clinically evident bilateral, painless enlargements of the jaws that are said to give the patient a cherubic appearance. Cherubism may appear in solitary cases or in many members of the same family, often in multiple generations. On radiography, the lesions exhibit bilateral multilocular radiolucent areas. Histopathologic evaluation reveals proliferating fibrous connective tissue containing numerous multinucleated giant cells. Since the first description of this condition in 1933, almost 200 cases have been reported. We describe cherubism in 2 siblings and briefly review the literature on this subject.

Adolescent↗
PubMed2003

Osteochondroma of the mandibular condyle.

Osteochondroma is one of the most common benign tumors of the axial skeleton, but is rarely found in the facial bones. When present, the tumor is most often reported to affect the mandibular coronoid process. Osteochondroma of the mandibular condyle is extremely rare. A case is presented of a massive osteochondroma of the mandibular condyle leading to facial asymmetry and disturbed occlusion. The diagnosis was confirmed by radiological and histological examination.

Adult↗
PubMedDate not supplied

Bifid mandibular condyles: report of four cases.

UNLABELLED: Anatomic variations in the condylar morphology, like bifid mandibular condyles, are a relatively uncommon anomaly. We report four cases (two in patients and two in archived specimens) of bifid mandibular condyles with emphasis on their aetiopathogenesis and radiographic features. A case of bifid mandibular condyles in a patient with rheumatoid arthritis is reported which, to the best of our knowledge, is the first reported case in the literature. CLINICAL RELEVANCE: Anatomical variations, like bifid mandibular condyles, may mimic a fracture/tumour. Therefore, knowledge and awareness about this entity is important for a general dental practitioner.

Arthritis, Rheumatoid↗