Biomedical subjects

Keith Sanford

Publications and source records attributed to Keith Sanford.

5 recordsLinked to original sources

PubMed2006

Characterizing aggressive behavior in a forensic population.

The concept of a dichotomous versus a continuous aggression model continues to be debated within the research literature. The Impulsive/Premeditated Aggression Scale (IPAS; M. S. Stanford, R. J. Houston, C. W. Mathias, et al., 2003) is a newly developed self-report instrument designed to classify an individual's aggressive behavior as predominantly premeditated or predominantly impulsive. The IPAS consists of 30-items that are scored on a 5-point Likert scale. This study used a nonrandom sample of convenience (N = 85) from a forensic state hospital. Principal-components analysis of the 30 items revealed 2 distinct factors (Impulsive and Premeditated Aggression), which accounted for 33% of the variance. The results of this study further validate the bimodal classification of aggression through its application to a forensic sample. The implications for general assessment, diagnosis, and treatment are discussed.

Adult↗

PubMed2006

Communication during marital conflict: when couples alter their appraisal, they change their behavior.

In a sample of 77 recently married couples, within-person variance in cognitive appraisal was expected to predict corresponding within-person variance in communication behavior during conflict. Three types of appraisal were considered: expectancies of partner understanding, expectancies of partner negative communication, and attributions. Couples were observed in 4 different conflict conversations, completed during 2 assessment sessions, and appraisals were assessed prior to each conversation. Hierarchical linear modeling was used to analyze within-person effects. Changes from one conversation to the next in all 3 types of appraisal predicted corresponding within-person change in communication, and many effects were larger for wives than for husbands. Results were strongest for expectancies of partner understanding. Expectancies predicted change in one's own behavior after controlling for the accuracy of the expectancy.

Adult↗

PubMed2005

Attributions and anger in early marriage: wives are event-dependent and husbands are schematic.

Two types of attribution believed to predict anger in married couples were investigated. Wives' anger was expected to be predicted by event-dependent attributions, appraisals based on the unique aspects of one's current situation. Husbands' anger was expected to be predicted by schematic attributions, appraisals based on one's global sentiment in the relationship. Seventy-seven recently married couples attended 2 assessment sessions, and each couple identified 4 incidents pertaining to unresolved relationship issues. Participants rated their event-dependent attributions and their anger prior to a discussion for each incident. They also completed questionnaires regarding schematic attributions and relationship sentiment. Hierarchical linear modeling was used to distinguish between the 2 types of attribution. Strong support was found for the expected gender differences. Results suggest that wives are particularly attentive to the details of interpersonal interaction.

Adult↗

PubMed2002

Latanoprost and brimonidine: therapeutic and physiologic assessment before and after oral nonsteroidal anti-inflammatory therapy.

PURPOSE: To assess, before and during oral nonsteroidal anti-inflammatory drug coadministration, latanoprost's and brimonidine's hypotensive action in eyes at risk of glaucomatous progression, assessing the effect of each drug on ocular perfusion and visual function. METHODS: Twenty consenting adults with open-angle glaucoma or ocular hypertension underwent a double-masked, bilateral, randomized prospective study. Treatment started with either latanoprost 0.005% in the morning and placebo in the evening, or brimonidine 0.2% twice daily in one eye; after 1 week starting the other in the fellow eye. After another week, oral indomethacin 25 mg four times a day, commenced for 2 more weeks. Intraocular pressure, ocular circulation, and visual function were monitored pretreatment, after unilateral monotherapy (day 7), bilateral ocular therapy (day 14), and coadministered oral indomethacin (day 28). Intrasubject differences (interocular and intraocular relative to baseline) were determined by two-tailed paired t test. RESULTS: A loss of the significance of intraocular pressure reduction with brimonidine was noted after oral indomethacin coadministration (-14%; P =.004 for brimonidine alone versus -11%; P =.3 with indomethacin). Significant intraocular pressure reduction with latanoprost persisted despite indomethacin (-25%; P <.0001 for latanoprost alone versus -30%; P <.0001 with indomethacin). Pulsatile ocular blood flow increased 40% with latanoprost, but was unchanged with brimonidine (interdrug difference, P =.004). Midperipheral retinal microcirculation increased 23% (P =.03) with latanoprost. Humphrey perimetry and contrast sensitivity remained consistently at or above baseline with both latanoprost and brimonidine. Indomethacin had no significant effect on ocular perfusion or visual function measures. CONCLUSIONS: Circulatory and hydrodynamic findings differed substantially for the two drugs. The loss of significance of intraocular pressure reduction with brimonidine during indomethacin treatment may be clinically important.

Administration, Oral↗

PubMed2002

Psychometric evaluation of the depressive personality disorder inventory.

The purpose of this study was to evaluate the psychometric properties of the Depressive Personality Disorder Inventory (DPDI; Huprich, Margrett, Barthelemy, & Fine, 1996). The DPDI was found to have strong internal consistency in both an undergraduate and a veteran, psychiatric outpatient population. The DPDI had significant, positive correlations with other measures of depressive personality, supporting its convergent validity. These relationships remained even after controlling for state-like depression, suggesting that the DPDI has incremental validity. The DPDI also significantly predicted scores on measures of interpersonal loss, even after controlling for state-like depression, suggesting that the DPDI has good construct validity. In support of discriminant validity, the DPDI was more correlated with another measure of depressive personality than it was with measures of other personality disorders. Finally, the DPDI had strong diagnostic efficiency statistics: (a) Sensitivity = .82, (b) Specificity = .80, (c) Positive Predictive Power = .75, (d) Negative Predictive Power = .86, and (e) Overall Diagnostic Power = .81. It appears that the DPDI has good psychometric properties.

Adult↗