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Biomedical subjects

Kelly M Shields

Publications and source records attributed to Kelly M Shields.

8 recordsLinked to original sources
PubMed2006

Use of sildenafil for female sexual dysfunction.

OBJECTIVE: To review the pathophysiology of female sexual dysfunction (FSD) and the literature regarding the use of sildenafil in its treatment. DATA SOURCES: Literature was accessed through MEDLINE (1966-April 2006), Iowa Drug Information Service (1966-April 2006), EMBASE (1966-April 2006), and bibliographies of pertinent articles. Search terms included female sexual dysfunction; sexual dysfunction, psychological; phosphodiesterase inhibitors; and sildenafil. DATA SYNTHESIS: The lack of a clear understanding of FSD contributes to the limited treatment options available. Studies regarding the safety and efficacy of the phosphodiesterase 5 inhibitor sildenafil in the management of FSD were evaluated. Many trials have been of poor quality, making clinical application of their results difficult. The current literature does not show sildenafil to be an effective treatment option for FSD. CONCLUSIONS: Treatment of FSD should include both physical and psychological components. Based on the limited data available, it appears that sildenafil, while well tolerated, offers little or no benefit to most patients with FSD.

Female↗
PubMed2005

Treating pregnancy-related nausea and vomiting with ginger.

OBJECTIVE: To review literature assessing the safety and efficacy of the use of ginger to treat nausea and vomiting in pregnancy. DATA SOURCES: Iowa Drug Information Service (1966-September 2004), International Pharmaceutical Abstracts (1971-September 2004), MEDLINE (1966-September 2004), and EMBASE (1966-September 2004) were searched. Key terms included ginger, nausea, vomiting, emesis, and pregnancy. DATA SYNTHESIS: Studies evaluating the safety and efficacy of ginger in the management of nausea and vomiting in pregnancy were reviewed. Various doses and forms of ginger were used to treat women during their first and second trimesters of pregnancy. Ginger has been shown to improve the symptoms of nausea and vomiting compared with placebo in pregnant women. CONCLUSIONS: While data are insufficient to recommend ginger universally and there are concerns with product quality due to limited regulation of dietary supplements, ginger appears to be a fairly low-risk and effective treatment for nausea and vomiting associated with pregnancy. In low doses, this may be appropriate for patients not responding to traditional first-line therapies.

Clinical Trials as Topic↗
PubMedDate not supplied

National survey of dietary supplement resources at drug information centers.

OBJECTIVE: To assess the resources drug information centers are currently using to respond to dietary supplement information requests and to determine the frequency with which drug information centers are used as sources of information on dietary supplements. DESIGN: Cross-sectional survey. SETTING: United States. PARTICIPANTS: 116 drug information centers. INTERVENTIONS: Mail survey that collected information on the use of drug information centers for dietary supplement information requests and the dietary supplement-specific resources available at and used in these centers. MAIN OUTCOMES MEASURES: Survey responses, evaluated using descriptive statistics. RESULTS: Drug information centers received a relatively small number of requests for information related to dietary supplements, and most such requests came from consumers. The centers had a number of resources available to assist in responding to those requests, with Facts and Comparisons' The Review of Natural Products and the print version of Natural Medicines Comprehensive Database being the resources most often at hand. The majority of respondents believed their centers were "usually able" to respond to the requests received. CONCLUSION: Drug information centers are often overlooked as sources of information about dietary supplements; however, centers have resources that are, by self-assessment, sufficient to respond to dietary supplement information requests. Great variation exists among centers in the resources available to address requests, with just two resources, the Review of Natural Products and the print version of Natural Medicines Comprehensive Database, available to more than three-fourths of the respondents.

Data Collection↗