Multicenter strategy for the development of catalytic enantioselective nucleophilic alkylation of ketones: Me2Zn addition to alpha-ketoesters.
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Biomedical subjects
Ken Funabashi
Publications and source records attributed to Ken Funabashi.
Recent progress in asymmetric two-center catalysis.
Recent progress using two types of enantioselective two-center catalysts, Lewis acid-Brönsted base and Lewis acid-Lewis base bifunctional complexes, is described. The first part of this review discusses improvements in the syn-selective direct catalytic enantioselective aldol reaction and 1,4-addition reaction of a 2-hydroxyacetophenone derivative using a Zn-linked-BINOL complex. In the second part, we describe the development of catalysts displaying Lewis acidity and Lewis basicity in a catalytic enantioselective cyanosilylation of aldehydes and the logical extension to a tetrasubstituted carbon synthesis through a Reissert-type reaction and a cyanosilylation of ketones.
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