Biomedical subjects

Ken'ichi Isobe

Publications and source records attributed to Ken'ichi Isobe.

2 recordsLinked to original sources

PubMed2005

Serum total acid phosphatase for monitoring the clinical course of giant cell tumors of bone--26 patients with 5 local recurrences.

BACKGROUND: Giant cell tumor of bone (GCT) is a bone-destroying tumor that sometimes recurs locally after treatment. A recent study showed increased levels of serum total acid phosphatase (TACP). METHODS: We assessed TACP in the serum of 26 patients with primary GCT, and in 5 of them who developed a local recurrence. RESULTS: We found a correlation between TACP level in serum and tumor size. TACP levels that were elevated preoperatively in patients with GCT became normalized after surgery, but increased in 3 of the 5 patients with local recurrence. INTERPRETATION: TACP could be used as a tumor marker for monitoring response to treatment of GCT.

Acid Phosphatase↗

PubMed2003

Bilateral solid parameniscal masses in the knees.

Parameniscal cysts of the knee joint are usually considered to be minor asymptomatic lesions associated with meniscal injury. We report on a rare case of bilateral knee masses in the medial soft tissues that resembled parameniscal cysts in terms of location and structure. The patient was an 80-year-old woman with severe osteoarthritis. Arthroscopy detected no meniscal tears in either knee. Arthrotomy with regional excision of the masses was required. The solid masses showed a capsular outer layer that contained fibrin deposits, granulation tissue, and fibrous cartilage fragments from the meniscus. We hypothesize that these unusual masses represent senescent or "ancient" meniscal cysts, the result of long-term fibrous degeneration of previous parameniscal cysts, and may co-occur with severe osteoarthritis and meniscal degeneration.

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