Biomedical subjects

Kenichi Tobisu

Publications and source records attributed to Kenichi Tobisu.

4 recordsLinked to original sources

PubMed2006

Function-preserving surgery for urologic cancer.

Radical surgery that is intended to cure cancer disease tends to cause some damage to the operated organ and the quality of life of the patient. It is now a worldwide trend to preserve the function and minimize the operative damage to the patient, without compromising the oncological outcome. In urologic cancers, nephron-sparing surgery for kidney tumors, and nerve-sparing procedures in radical cystectomy and radical prostatectomy for retaining potency are now more frequently used for providing better quality of life after surgery. New constructive surgeries such as neobladder formation and nerve graft techniques after complete removal of the cavernous nerve have been developed for recovering the lost function.

Carcinoma, Renal Cell↗

PubMed2006

Urothelial carcinoma (clear cell variant) diagnosed with useful immunohistochemistry stain.

The case is reported of urothelial carcinoma (clear cell variant) that was diagnosed with useful immunohistochemistry stain. A 70-year-old man, who had undergone left radical nephrectomy for renal cell carcinoma in August 2003 and partial lobectomy for pulmonary metastasis in May 2005, complained of hematuria in June 2005. On evaluation, a papillary pedunculated tumor was detected in the left wall of the urinary bladder. A transurethral resection of the bladder tumor (TUR-Bt) was performed in July 2005. The pathological diagnosis was difficult due to diffuse clear cell appearance. Immunohistochemistry stain showed urothelial carcinoma, not metastasis of the renal cell carcinoma. Finally it was diagnosed as urothelial carcinoma clear cell variant. Urothelial carcinoma has many variants that show a variety of appearances and characteristics. These should be well known before medical therapy is initiated.

Adenocarcinoma, Clear Cell↗

PubMed2006

[Primary clear cell carcinoma of the ureter: a case report].

In September 2003, a 58-year-old woman complained of bladder irritation and urinary frequency. She was admitted to a nearby hospital, and an evaluation was performed. Urine cytology revealed a class V, and a tumor was detected in the lower left ureter with mild hydroneprhosis of the left kidney. We performed a left ureteronephrectomy with partial cystectomy in April 2004. The pathological diagnosis was clear cell carcinoma with small foci of conventional urothelial carcinoma of the left ureter (pT3pN0, G3 > G2, INFgamma). And now she lives well without recurrence in August 2005. This is the first case report of clear cell carcinoma of the ureter in Japan.

Adenocarcinoma, Clear Cell↗

PubMed2006

[A case of inflammatory pseudotumor of the urinary bladder that was difficult to differentiate from sarcoma].

On September 25th, 2003, a 39-year-old man complained of asymptomatic gross hematuria. He was admitted to a nearby hospital and evaluated. Cystoscopy revealed a non-papillary broad base tumor in the anterior wall of the bladder. On October 2nd, a TUR-Bt was performed. The pathological diagnosis was difficult to determine because mitosis and nuclear pleomorphism were apparent. He next came to our hospital for further evaluation. We diagnosed his condition as an inflammatory pseudotumor of the bladder because fibroblasts and inflammatory cells had increased; however, we did not see abnormal nuclear mitosis or severe pleomorphism. Although we did not perform a complete TUR-Bt, the mass regressed spontaneously and did not reoccur. The presence of mitosis and mild nuclear pleomorphisms make certain cases difficult to diagnose as inflammatory pseudotumors. Inflammatory pseudotumors are generally considered benign, and some cases regress spontaneously. It is important that we are able to identify and characterize these pseudotumors in order to avoid more invasive surgeries whenever possible.

Adult↗