Focal segmental glomerulosclerosis in a girl with myelodysplastic syndrome.
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Adolescent↗
Biomedical subjects
Kenji Hamaoka
Publications and source records attributed to Kenji Hamaoka.
Renal tubular regeneration by bone marrow-derived cells in a girl after bone marrow transplantation.
Recent studies have indicated that bone marrow cells can contribute to regeneration of the kidney in experimental models. However, renal regeneration by apparent bone marrow-derived cells has not been shown previously in humans. The authors here report on a 7-year-old girl who received whole bone marrow transplantation from a male donor, and the contribution of bone marrow cells to the regeneration after renal damage was shown by in situ hybridization for the Y chromosome on autopsy specimens of the kidney. This observation suggests the clinical potential of bone marrow cells as a therapeutic option for renal injury.
Bone Marrow Transplantation↗
Usefulness of helical CT angiography and MRI in the diagnosis and treatment of pentalogy of Cantrell.
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Angiography↗
Application of helical computed tomographic angiography with differential color imaging three-dimensional reconstruction in the diagnosis of complicated congenital heart diseases.
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Angiography↗
Role of hydrogen peroxide in cyclosporine-induced renal tubular cell (LLC-PK1) injury.
We examined the role of hydrogen peroxide production in cyclosporine A (CsA)-induced LLC-PK1 injury. After exposure to CsA (0.1 microM - 100 microM), cytotoxicity assessed by lactate dehydrogenase release to the media increased dose-dependently. LLC-PK1 cells produced hydrogen peroxide, visualized by 2,7-dichlorodihydrofluorescein assay by the treatment with 100 microM CsA, that was blocked by the treatment with catalase. The cytotoxicity of CsA significantly decreased either by the treatment with catalase, mannitol, or deferoxamine, but not with superoxide dismutase. These results suggest the role of hydrogen peroxide as the source of hydroxyl radical, which mainly contributes to CsA-induced LLC-PK1 injury.
Animals↗