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Biomedical subjects

Kenneth J Young

Publications and source records attributed to Kenneth J Young.

5 recordsLinked to original sources

Ependymoma of the spinal cord presenting in a chiropractic practice: 2 case studies.

OBJECTIVE: The purpose of this study is to discuss the cases of 2 patients with previously undiagnosed primary spinal cord tumors presenting in a private chiropractic clinical setting. An overview of treatment and outcome for an ependymoma at T12-L1 and L1-L2 is discussed. CLINICAL FEATURES: One patient was a 46-year-old Hispanic woman with 3 to 4 years of intermittent backache that usually resolved with conservative care but failed to do so during an acute episode. Lower motor neuron signs, including bowel and bladder dysfunction, were revealed upon clinical assessment. The second patient, a 38-year-old white man under routine treatment, had no lower motor neuron signs or symptoms. INTERVENTION AND OUTCOME: Both patients were referred, one to a local hospital emergency department and the other directly to a neurosurgeon. Both underwent surgery. Upon returning home, the first patient received follow-up treatment primarily consisting of radiation therapy. Follow-up telephone interviews (3, 6, 12, 24, and 40 months) revealed the patient doing well. The second case did not require radiation therapy and was doing well at 4, 10, 12, and 18 months; the patient returned for unrelated treatment 1 year after the surgery. CONCLUSION: These cases show that with a careful history and patient examination, enough clinical data may be gathered to make an accurate health care determination under various conditions. It also illustrates the importance of interprofessional cooperation for various disciplines of health care providers regardless of training or specialty.

Adult↗

Unifocal Langerhans cell histiocytosis presenting as an aggressive bone lesion.

OBJECTIVE: To discuss a case of unifocal Langerhans cell histiocytosis (eosinophilic granuloma) presenting as an aggressive osseous destructive process. CLINICAL FEATURES: A 6-year-old girl had thigh pain of insidious onset that would wake her at night. Orthopedic testing reproduced local pain, and imaging revealed an osteolytic process in the femoral diaphysis with laminated periosteal reaction. INTERVENTION AND OUTCOME: The patient was referred for further evaluation; unifocal Langerhans cell histiocytosis was found at biopsy and spontaneous healing subsequently reported. CONCLUSIONS: Unifocal Langerhans cell histiocytosis may present with deceptive clinical and imaging findings, of which clinicians should be aware.

Bone Diseases↗

Salt-free synthesis of samarium-aluminum mixed-metal alkoxides: X-ray crystal structures of [[(i-Pr-O)(i-Bu)Al(mu-O-i-Pr)(2)Sm(O-i-Pr)(HO-i-Pr)](mu-O-i-Pr)](2), [(THF)(2)Sm(O-t-Bu)(2)(mu-O-t-Bu)(2)Al(i-Bu)(2)], Sm(OAr)(3)(THF)(3) (Ar = 2,4,6-Me(3)C(6)H(2)), [Nd(mu-OAr)(OAr)(2)(py)(2)](2) (Ar = 2,4,6-Me(3)C(6)H(2)), and (ArO)(3)Sm[(mu-O-t-Bu)(2)Al(2)(O-t-Bu)(4)] (Ar = 2,6-i-Pr(2)C(6)H(3)).

Reaction of equimolar quantities of Sm[N(SiMe(3))(2)](3) and Al(i-Bu)(3) with 6 equiv of iso-propyl alcohol in toluene leads to the formation of the mixed-metal alkoxide complex [[(i-Pr-O)(i-Bu)Al(mu-O-i-Pr)(2)Sm(O-i-Pr)(HO-i-Pr)](mu-O-i-Pr)](2) (1). An analogous reaction between 1:1 Sm[N(SiMe(3))(2)](3)/Al(i-Bu)(3) and 6 equiv of tert-butyl alcohol, followed by addition of THF, produces the THF adduct [(THF)(2)Sm(O-t-Bu)(2)(mu-O-t-Bu)(2)Al(i-Bu)(2)] (2). Compound 1 crystallizes in the space group P1 while 2 crystallizes in space group Cmcm. Cell parameters for 1: a = 11.028(2) A, b = 12.168(2) A, c = 12.879(2) A, alpha = 82.84(1) degrees, beta = 64.88(1) degrees, gamma = 70.80(1) degrees, Z = 1. Cell parameters for 2: a = 11.304(2) A, b = 22.429(4) A, c = 15.768(2) A, Z = 4. Attempts to prepare the bulkier derivatives result in the formation of lanthanide aryloxide species only; reaction between equimolar amounts of Ln[N(SiMe(3))(2)](3) (Ln = Sm, Nd) and Al(i-Bu)(3) with 6 equiv of HO-2,4,6-Me(3)C(6)H(2), followed by the addition of THF or pyridine, yields the Lewis base adducts Sm(OAr)(3)(THF)(3) (3) and [Nd(mu-OAr)(OAr)(2)(py)(2)](2) (4). Compound 3 crystallizes in the space group Pbca while 4 crystallizes in space group P2(1)/c. Cell parameters for 3: a = 16.5822(9) A, b = 15.5668(9) A, c = 29.902(2) A, Z = 8. Cell parameters for 4: a = 13.4496(8) A, b = 20.034(1) A, c = 16.206(1) A, beta = 113.782(1) degrees, Z = 2. Reaction of Al(2)(O-t-Bu)(6) with [Sm(OAr)(3)](2) (Ar = 2,6-i-Pr(2)C(6)H(3)) yields the adduct (ArO)(3)Sm[(mu-O-t-Bu)(2)Al(2)(O-t-Bu)(4)] (5), which crystallizes in the space group P2(1)/n. Cell parameters for 5: a = 14.0960(7) A, b = 27.3037(15) A, c = 16.7893(9) A, beta = 92.216(1) degrees, Z = 4.

Journal Article↗

Porcelain gallbladder.

OBJECTIVE: To discuss the case of a porcelain gallbladder found incidentally in a patient with low back and heel pain. CLINICAL FEATURES: A 70-year-old woman had low back pain, numbness in the left lower leg, and sharp pain in her left heel. Plain films of the lumbar spine necessitated diagnostic abdominal ultrasound, the findings of which were consistent with porcelain gallbladder. INTERVENTION AND OUTCOME: The patient has been recommended for prophylactic cholecystectomy and is concurrently being treated for mechanical low back and heel pain. CONCLUSIONS: Porcelain gallbladder is an uncommon finding; however, due to the greatly increased chance of malignancy, it must be considered in patients who have cystic type calcification in the right upper abdominal quadrant.

Aged↗

Spondylolysis of L2 in identical twins.

OBJECTIVE: To discuss the presence of spondylolysis at L2 in identical twins. CLINICAL FEATURES: Twin 61-year-old brothers reported insidious low back pain (LBP) of relatively recent onset. Both engaged in running as their main form of exercise. One had spondylolisthesis and history of significant traumatic incident; the other had no spondylolisthesis but a much more strenuous running regimen. INTERVENTION AND OUTCOME: Both patients underwent a course of chiropractic treatment for mechanical LBP and reported a 50% overall improvement in symptoms. CONCLUSIONS: Spondylolysis at L2 is uncommon, and although a familial component regarding weakness of the pars interarticularis has been demonstrated in the literature, spondylolysis at L2 in twins is extremely rare. Questions remain regarding the cause of spondylolisthesis in patients.

Diseases in Twins↗