Biomedical subjects

Kenta Takeda

Publications and source records attributed to Kenta Takeda.

3 recordsLinked to original sources

PubMed2006

[The use of questionnaires for rotating residents in evaluating training in anesthesiology].

BACKGROUND: We prepared questionnaires for the rotating residents during their assignment for anesthesiology in the novel Japanese residency programs for the year 2004. METHODS: Questionnaires consisting of 39 items with 235 model answers for these items were prepared. The residents underwent three interviews by these questionnaires over the three-month training period. The number of correct answers for these questionnaires was recorded and evaluated using a computer database software. RESULTS: There was no significant correlation between the results of these questionnaires and the subjective evaluation by supervisors conducted during clinical training. On stepwise regression analysis, the results of the questionnaires for "American Society of Anesthesiologists Physical Status", "contraindications for epidural anesthesia", "complications of general anesthesia" and "initial procedures for patients in the operating room" correlated with the subjective evaluation by supervisors. CONCLUSIONS: Stepwise regression analysis was shown to be helpful in improving the questionnaires regarding the training in anesthesiology.

Anesthesiology↗

PubMed2006

The application of the hemoglobin saturation sensor and indocyanine green (ICG) for blood flow measurement.

BACKGROUND: The aim in this study is to evaluate a new blood flow measurement applying a hemoglobin saturation sensor and indocyanine green (ICG) in circuit and animal models. METHODS: 1) In the basic study, the blood was mixed in a tube with ICG, and a near-infrared sensor was placed in this tube. The standard curve of the relationship between ICG concentration and optical density was obtained. 2) In the circuit model, the blood was circulated by the roller pump. ICG was injected in this circuit and its concentration was calculated from the change in optical density at 810 nm. Rate of flow was calculated based on the Fick's principle. The validity of this method was evaluated by Bland and Altman analysis. 3) In the animal model, a hemoglobin saturation sensor was inserted into three anesthetized dogs via the jugular vein, and iced ICG was injected for calculating cardiac output. Cardiac output was calculated by the same theory of the circuit model. The validity of this method was also evaluated by Bland and Altman analysis. RESULTS: 1) A standard curve was drawn from 11 different points (r2=0.99). 2) The calculated flow rate correlated well with the actual flow rate (r2=0.97). 3) The calculated cardiac output correlated well with results obtained with the thermodilution method. CONCLUSIONS: Application of a hemoglobin saturation sensor and ICG to blood flow measurement was reliable and useful in both circuit and animal models. This method may be clinically useful for measurement of blood flow.

Animals↗

PubMed2005

A new method for measuring total coronary blood flow using the lithium dilution method.

BACKGROUND: The aim in this study is to evaluate a new method of measuring total coronary blood flow (TCBF) in (1) an in vitro model and in (2) an animal model by the lithium dilution method. METHODS: (1) Ringer's solution was circulated in a closed circuit with the main flow as a systemic circulation, and the side flow as a coronary circulation by a roller pump. Two peaks originating from the main and side flow were recorded by the lithium dilution method. The flow was calculated using the Fick principle based on the ratio of the areas under the curve. The validity of this method was evaluated by Bland Altman analysis. (2) Four beagles were anesthetized and subjected to insertion of two pulmonary artery catheters. The position of the catheters was confirmed as being in the pulmonary artery and in the right atrium. Lithium chloride solution was injected into the pulmonary artery and the change in lithium concentration at the right atrium was recorded. TCBF was estimated by the method used in the in vitro study. RESULTS: (1) The calculated flow correlated well with the actual flow (r2 = 0.86). (2) The estimated TCBF at baseline, with low-dose nitroglycerin, and with high-dose nitroglycerin was 206 +/- 43.0 mL/min, 304 +/- 50.3 mL/min, and 348 +/- 50.1 mL/min, respectively (mean +/- SE). TCBF was significantly increased by nitroglycerin infusion. CONCLUSION: A new method of measuring TCBF using the lithium dilution method was reliable and useful both in vitro and in an animal model. This may be clinically useful method for measuring TCBF.

Animals↗