Biomedical subjects

Kevin L Caran

Publications and source records attributed to Kevin L Caran.

3 recordsLinked to original sources

PubMed2006

Heterodimerization studies of calix[4]arene derivatives in polar solvents.

[reaction: see text] Several calix[4]arene derivatives propylated on the lower rim and substituted on the upper rim with amino or carboxyl groups have been synthesized. Examples include calixarenes substituted with alanino (C- and N-linked), amino, carboxy, carboxyphenyl, and amidino groups. The self-assembly of these derivatized calixarenes into heterodimers has been studied by NMR in DMSO-d(6) or CD(3)OD with 5% aqueous phosphate buffer.

Journal Article↗

PubMed2002

Depth-profiling with giant vesicle membranes.

A phospholipid fluorescent-labeled in one of three locations was paired with a phospholipid labeled with a quencher in one of three locations within a host phospholipid bilayer. The various combinations of quenching efficiencies allowed the location of the fluorescent labels to be determined. It was found that all three labels (including one attached to the chain terminus) position themselves at the bilayer surface. The tendency of even modestly polar molecules (or sections of molecules) to gravitate to the membrane surface has numerous practical ramifications.

Boron Compounds↗

PubMed2002

Gemini-induced columnar jointing in vitreous ice. Cryo-HRSEM as a tool for discovering new colloidal morphologies.

A gemini surfactant is able to promote columnar jointing in vitreous ice where long pillars, often of hexagonal cross section, are formed. This jointing is visible by cryo-high-resolution scanning electron microscopy (cryo-HRSEM), in which colloidal suspensions in bulk water are cooled rapidly in liquid ethane, thereby avoiding the potential artifacts with other types of EM. The jointing is proposed to arise from a new type of colloidal morphology where the surfactant self-assembles into hexagonal columns. Evidence for this mechanism comes from a cryo-HRSEM photo of an ice-free hexagonal "skeleton" composed of surfactant. Cryo-HRSEM, a method that is just beginning to realize its potential, would seem to have a promising future in the discovery of additional and as yet unimagined colloidal structures.

Journal Article↗