Biomedical subjects

Kexin Yang

Publications and source records attributed to Kexin Yang.

2 recordsLinked to original sources

PubMed2003

Molecular diversity of hydroxamic acids: part II. Potential therapeutic applications.

A hydroxamic acid moiety has been demonstrated as the key structural element in many highly potent and selective inhibitors against a variety of metalloprotease enzymes, such as MMPs, TACE, HDAC, PDF, etc. Over the last several years, there has been a rapid growth of literature and patent applications dealing with the development of the hydroxamic acid-based inhibitors. This review highlights the most recent examples to show their potential therapeutic applications.

Antineoplastic Agents↗

PubMed2003

Molecular diversity of hydroxamic acids: part I. Solution- and solid-phase synthesis.

Hydroxamic acid derivatives are an important class of molecules with a variety of pharmaceutical properties. Over the last decade steady progress has been made in the development of efficient methods for the syntheses of hydroxamic acid derivatives. This mini-review covers the most recent publications that highlight current strategies and syntheses of bioactive molecules containing the hydroxamate moiety in both solution- and solid-phase.

Acylation↗