Biomedical subjects

Kh Abel'

Publications and source records attributed to Kh Abel'.

3 recordsLinked to original sources

PubMedDate not supplied

[Damage by gamma rays and heavy ions to superhelical structures of nuclear DNA].

Chinese hamster cells (V79-4), human lymphocytes and mouse ascites cell were exposed to gamma-rays and heavy ions (4He and 12C). Sedimentation of complexes containing DNA was studied after cell lysis by centrifugation in a neutral sucrose gradient. The distinctions noted after irradiation with gamma-rays and heavy ions are consistent with the idea of the superhelical organization of DNA into discrete and membrane-bound compact units. According to the estimates made the diameter of these complexes was approximately 0.2 micron and DNA content, about 2 X 10(9) dalton.

Animals↗

PubMedDate not supplied

[Double-stranded DNA breaks and inactivation of mammalian cells in relation to the LET of the radiation--comparison between experiment and theory].

In experiments on Chinese hamster cells the survival curves and the yield of double-strand DNA breaks were determined after irradiation at different LET. The comparison of the experimental results and the survival curves calculated on the basis of Günter-Schultz's theory of radiation inactivation of cells has demonstrated that radiation-induced double-strand DNA breaks are responsible for the lethal effect of radiation on cells.

Alpha Particles↗

PubMedDate not supplied

[Multicellular spheroids for use in radiobiological experiments].

Cell spheroids are conglomerates of closely arranged cells with reciprocal effects among them. Spheroids are histologically similar to nodulary tumours. Cells constituting these spheroids are heterogenous in their sensitivity to X-rays and fast neutrons. Radiosensitivity of cells in a small spheroid is lower than that of similar cells grown in a monolayer.

Cell Survival↗