Biomedical subjects

Kh Getov

Publications and source records attributed to Kh Getov.

9 recordsLinked to original sources

PubMed1990

[An evaluation of the toxic and antitumor action of farmorubicin administered to H-strain mice with Ehrlich ascitic cancer].

The toxic and antitumour action of farmorubicin was investigated in experiments on mice. Data on the high antitumor activity were obtained after single application of the drug and at 5-day treatment of mice bearing the Ehrlich ascites tumour. It has been established that farmorubicin used in the tolerant dose was comparatively nontoxic--nonmyelotoxic. At higher doses the toxic damages manifested in different periods and depended on the employed doses. A decrease in the heart weight has permitted revealing the formorubicin-induced cardiotoxicity which was confirmed (after 5 injections of the preparation in a dose of LD 50) by electron microscopy.

Animals↗

PubMed1989

[Experimental pharmacologic and morphologic study of new platinum complexes].

Antineoplastic and toxic properties of two newly synthesized complexes of platinum (II)--with isovaleric acid and with cystine, were studied on mice with ascitic tumour of Ehrlich. The studies were compared with cis-diaminodichloroplatinum (II) (cisplatinum). Data were obtained for high antineoplastic activity and inhibiting influence of the synthesis of DNA of cisplatinum. There was therapeutic effect on the animals with ascitic tumour of Ehrlich after usage of cisplatinum. There was therapeutic effect on the animals with ascitic tumour of Ehrlich after usage of the complex of platinum with isovaleric acid and no effect after application of the complex with cystine. Information was obtained by histological examination for reduction in organic toxicity of the newly synthesized compounds against renal tissue. The necessity from multiple parametric strategy of the experiment, creating a possibility for logic direction of the investigation according to the aim-search for metallic complexes with reduced toxicity, is confirmed by the conducted study.

Animals↗

PubMed1988