[Epidural analgesia in the surgical treatment of patients with diabetes mellitus].
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Biomedical subjects
Publications and source records attributed to Kh Kh Khapiĭ.
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Glucose release and lactate uptake by the brain during coma is discussed. A hypothesis of autonomous gluconeogenesis in the brain is suggested. To substantiate the hypothesis use is made of the literature data on the presence in the brain of stimuli, and its provision with substrates and gluconeogenetic enzyme apparatus. Special attention is paid to the problem of gluconeogenesis energy supply during hypoxia, using proton or sodium potentials.
The article confirms an earlier discovered phenomenon that during comas and in post-coma periods the brain releases glucose and consumes lactate. It is suggested that the phenomenon is based on glucogenesis taking place in the brain from non-carbohydrate glucose precursors, which is phylogenetically predetermined and biologically expedient.
Osteoplastic operations on the jaws were carried out in 19 patients aged 14-64 under moradol anesthesia. The mean length of the operation was 3 hours. The authors come to a conclusion that moradol in a dose of 0.3 mg/kg b. w. ensures adequate anesthesia, with a high level of analgesia persisting in the immediate postoperative period.
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