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Biomedical subjects

Kh Marinov

Publications and source records attributed to Kh Marinov.

18 recordsLinked to original sources
PubMed1991

[Changes in the lungs in progressive systemic scleroderma].

In 24 patients with progressive systemic scleroderma the respiratory disturbances, X-ray, scintigraphic and clinical deviations as well as the statistical correlations between them are described. The functional examination of respiration revealed lowered diffusion capacity, restrictive type of ventilatory failure and hypoxemia as the most frequent disturbances. The functional examination of respiration is correlated with the X-ray changes in the lungs in these patients.

Acid-Base Equilibrium↗
PubMed1988

[A case of large mixed thrombus in the left heart atrium].

A case is presented of a woman with a combined Rheumatic mitral valvular disease with a large mixed thrombus (65 mm) in the left atrium diagnosed post mortem. Such cases are very rare. In the course of the investigation of the patient many difficulties arose in spite of the use of modern instrumental methods. The precise and timely diagnosis of a thrombus in the left atrium allows an early radical treatment.

Female↗
PubMed1988

[Dynamic changes in the functional respiratory indices in chronic obstructive lung disease].

The basic functional respiratory indices were followed up in 50 patients suffering from various forms of chronic obstructive pulmonary disease before and after treatment. A decrease of the dynamic indices followed up was found: inspiration indices--FEV 1% (forced expiratory volume), FVC% (forced vital capacity), FEV 1/FVC%, FEV 1/VC%; flow indices--MEF 25% (maximal expiratory flow), MEF 50% MEF 75%, PEF% (peak expiratory flow), MEF/FVC%, MMEF 25-70% (maximal mean expiratory flow). A decrease of vital capacity and of diffusion capacity was also found. The ratio RV/TLC% (residual volume/total lung capacity) was increased and a general hyperventilation was established. Moderate hypoxemia and lowered saturation by normocapnia and normal pH were also established. The control examinations after treatment showed improvement of all indices followed up.

Blood Gas Analysis↗
PubMed1988

[Changes in the coagulation status of patients with chronic obstructive lung disease following the electrophoretic use of heparin].

49 patients with chronic obstructive pulmonary disease and 40 healthy persons were examined. The hemocoagulation state indices were followed up before and after treatment. The patients with chronic obstructive pulmonary disease were classified into two groups: I gr.--treated without drugs acting on the hemocoagulation factors, II gr.--treated with heparin applied by electrophoresis. Significant changes of some of the basic indices of hemostasis were found. Following electrophoretic application of heparin they were considerably improved compared with the control group of patients treated without heparin. This kind of treatment is well tolerated by the patients and does not lead to untoward reactions.

Adult↗
PubMed1987

[Adrenal function in patients with chronic obstructive lung diseases].

The hydrocortisone and ACTH blood levels, 17-hydroxycorticosteroids urine excretion and suprarenal function stimulation with Synacthen were studied in 22 patients with chronic obstructive pulmonary disease and 12 healthy persons as controls. The results show the presence of reliably higher hydrocortisone and 17-hydroxycorticosteroids levels in patients with low partial oxygen pressure as well as a higher ACTH plasma level and a strong Synacthen stimulation. After a comprehensive treatment including oxygen therapy the blood concentrations of hydrocortisone, ACTH, 17-hydroxycorticosteroids fell to levels found in healthy persons. The study shows that hypoxemia stimulates the suprarenal-cortex secretion.

17-Hydroxycorticosteroids↗
PubMed1987

[Left heart ventricle in chronic cor pulmonale patients. Etiological, pathomorphological and organ weight measurement studies].

The histories and the results of the postmortem examinations of 507 patients with chronic pulmonary heart disease were studied. In 62.6% of them left ventricular hypertrophy was found. As probable causes for this left ventricular hypertrophy are suggested: arterial hypertension, ischemic heart disease, hypoxemia, hypercapnia, heart failure, diabetes mellitus. The weight measurement correlations between the left and the right heart ventricles were studied in: "normal hearts", hearts with right ventricular, hypertrophy only, hypertrophy of both ventricles, left ventricular hypertrophy only. A correlation between the mass increase and the wall thickness of the ventricles was established. In the patients with chronic pulmonary heart disease and hypertrophy of both ventricles the mass and the wall thickness of the ventricles increase simultaneously. The possible pathogenetic mechanisms of the left ventricular involvement in patients with chronic pulmonary heart disease are discussed.

Cardiomegaly↗
PubMed1987

[Favorable therapeutic results in a patient with alcoholic cardiopathy].

A case of a 52-year-old man with alcoholic myocardiopathy with significant enlargement of the heart and heart failure is described. After a long treatment, improvement of the pump and contractile functions of the myocardium was achieved. The case indicates that significant improvement could be achieved by a long treatment and prompt discontinuance of alcohol abuse.

Cardiomyopathy, Alcoholic↗
PubMed1986

[Immunological changes in the exacerbated form of chronic obstructive pulmonary disease].

Ninety four subjects were examined, 42 of them with chronic obstructive pulmonary disease (COPD) and 52--healthy. The following indices followed up: immunoglobulins G, A, M, fraction of the complement--C3 and C4, alpha 2-macroglobulin (alpha 2MG), alpha 1-antitrypsin (alpha 1 AT). The following methods were applied: radial immunodiffusion according to Manccini et al and counter-electrophoresis on cellulose-acetate. Antisera and standards of the firm "Behring"--FRG were used. The data obtained are compared with those from the group the healthy subjects. Changes were established, manifested in increased level of immunoglobulin (IgG) and considerable reduction in the values of alpha 1AT, in the patient, with exacerbated form of COPD. No substantial deviations in IgA, complement fractions and alpha 2MG were established.

Adult↗
PubMed1986

[Radiocardiographic assessment of hemodynamics in different types of acquired heart valve defects].

The hemodynamic disorders in various types of cardiac defects were studied in 133 subjects, 82 of them patients with aquired combined valvular defects of the heat and the results obtained were juxtaposed. The hemodynamics was determined by the method of quantitative radiocardiography (QRCG). The volume of circulating blood was determined as well as the indices of cardiac output, ventricular, pulmonary quantities and the indices of aortic route. The results obtained by the numerous indices followed up, juxtaposed to the separate defects, reveal hemodynamic disorders, manifested to various degrees in the various heart defects. The hemodynamic disorders in two-axis heart defects (mitral and aortic) proved to be most severe. Stroke and minute volumes were diminished. The time for filling of the right and left heart was twice prolonged. The rate of pulmonary and systematic hemodynamics was retarded two and a half times. Better manifested hemodynamic disorders advance in mitral stenosis as compared with mitral insufficient. The hemodynamic disorders in combined aortic defects proved to be the lightest.

Adolescent↗
PubMed1985

[Changes in respiratory function, functional and true intrapulmonary shunts and acid-base state depending on the type of heart defect].

The respiratory disorders in various kinds of heart defects were studied in 226 patients with acquired heart defects. The following indices were determined: external respiration, alveolar ventilation, alveolar-capillary diffusion, functional and real intrapulmonary shunts and acid-base state. The complex studies via numerous indices, juxtaposed in the separate defects, revealed various stages of manifestation of the respiratory disorders according to the kind of defect, at identical degree of cardiac insufficiency. The lightest proved to be the respiratory disorders in combined aortic defects and most manifested--in biaxial defects (mitral and aortic). In mitral defects with predominant stenosis, the respiratory disorders are better manifested as compared with those with predominant insufficiency, and for some of the indices--they are considerable.

Acid-Base Equilibrium↗
PubMed1985

[Respiratory disorders in acquired heart valve defects with various degrees of heart failure].

The respiratory disorders with various degrees of cardiac insufficiency were studied in 226 patients with acquired heart defects. The indices characterizing the external respiration, alveolar ventilation, alveolar-capillary diffusion, functional and real intrapulmonary shunts and acid-base state were followed up. The results from the numerous indices followed up significantly express the progressive intensification of respiratory disorders with the advancement of cardiac insufficiency. In stage I of cardiac insufficiency, prior to the manifestation of clinical signs of pulmonary stasis, distinct disturbances were established in DLCO, Qs/Qt, PaO2, which, to a great extent, characterize the early respiratory disorders and have a definite importance for the diagnostic and therapeutic behaviour. Most severe are the functional disorders in respiratory system in stage II B of cardiac insufficiency.

Acid-Base Equilibrium↗
PubMed1978

[Functional changes in the respiratory system in acquired heart defects].

A total of 52 patients were examined, 8 out of them healthy and 44 patients with acquired valves defects without accompanying pulmonary and other diseases. The indices of external respiration, alveolar-arterial gradients for O2 and CO2 were followed up as well as diffusion capacity of lungs and its components, acid-alkaline balance, functional and real shunts in the pulmonary circulation, etc. The summed up results revealed that considerable disturbances in external respiration, leading mainly to a restrictive ventilatory syndrome, developed with the lesion of myocardium and valve apparatus of the heart. The values of diffusion lung capacity for CO and its components--Dm and Vc are decreased. O2 and CO2 metabolism was disturbed. The results pointed to a moderately manifested hypoxemia, marked elevation of alveolar-arterial gradients for O2 and presence of respiratory alkalosis. A considerable increase in the functional and real shunts of the lungs were established, manifestations of the disturbed pulmonary ventilation and hemodynamics in the pulmonary circulation.

Acid-Base Equilibrium↗