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Biomedical subjects

Khodas MYa

Publications and source records attributed to Khodas MYa.

2 recordsLinked to original sources

Hemoperfusion effect on oxygen-carrying function of preserved donor blood and erythrocytic mass.

The purpose of the study was to explore the preserved (7-21 days) donor blood and erythrocytic mass, following perfusion through hemosorbent SKN-D. After the sorption the oxygen-transport function of erythrocytes was found to improve considerably (oxyhemoglobin dissociation curve was shifted to the right on average by 4-4.2 mm Hg). The energy supply became better (ATP level was increased by 38-59%). In view of the above, long-preserved blood and erythrocytic mass following their perfusion through SKN-D hemosorbent can be considered a sufficiently valid transfusion medium.

Biological Transport↗

Hemoconcentration during open heart operations.

During surgical procedures with extracorporeal circulation the method of hemoconcentration by means of blood ultrafiltration was employed to control hemodilution in 84 patients. Disposable plate or hollow fiber dialyzers and a specially designed hemoconcentrator were used. The amount of ultrafiltrate received from one patient varied between 750 and 6250 cc, with a mean of 2588 +/- 221 cc, which was almost similar to the amount of cardioplegic solution given to the patients. Hemoconcentration by means of ultrafiltration is a relatively simple, safe and effective method of hemodilution control during extracorporeal circulation. In contrast to the centrifuging method (plasmapheresis) it preserves plasma proteins. The method is indicated for patients undergoing surgical procedures with heart-lung bypass and uncontrolled profound hemodilution, especially for patients with renal insufficiency. Hemoconcentration helps to reduce blood loss and bank blood usage. The employment of this method is not accompanied by any significant disturbances in humoral homeostasis. Hemoconcentration requires a larger volume of electrolyte solutions (sodium bicarbonate, potassium chloride) during heart-lung bypass. The method can be recommended for routine use in clinics operating on the open heart.

Blood↗