Biomedical subjects

Kin-Hung Chow

Publications and source records attributed to Kin-Hung Chow.

3 recordsLinked to original sources

PubMed2003

Multivalent antibiotics via metal complexes: potent divalent vancomycins against vancomycin-resistant enterococci.

Dimers of vancomycin (Van), linked by a rigid metal complex, [Pt(en)(H(2)O)(2)](2+), exhibit potent activities (MIC approximately 0.8 mug/mL, approximately 720 times more potent than that of Van itself) against vancomycin-resistant enterococci (VRE). The result suggests that combining metal complexation and receptor/ligand interaction offers a useful method to construct multivalent inhibitors.

Anti-Bacterial Agents↗

PubMed2003

Self-assembled multivalent vancomycin on cell surfaces against vancomycin-resistant enterococci (VRE).

A vancomycin (Van) derivative self-assembles in a phosphate buffer as a divalent Van and on cell surfaces as a multivalent Van, which offers potent activity against VRE.

Anti-Bacterial Agents↗

PubMed2002

Hydrophobic interaction and hydrogen bonding cooperatively confer a vancomycin hydrogel: a potential candidate for biomaterials.

Antibiotic hydrogels based on a vancomycin (Van) derivative, formed by self-assembling Van-pyrene (1) in water, using the pi-pi interaction of pyrene moieties and hydrogen bonding of Vans, promise a new way to make novel biomaterials.

Anti-Bacterial Agents↗