Biomedical subjects

Kiyoaki Tsukahara

Publications and source records attributed to Kiyoaki Tsukahara.

6 recordsLinked to original sources

PubMed2026

Surgical management of jugular foramen meningiomas: a function-prioritized perioperative workflow.

OBJECTIVE: Jugular foramen meningiomas are challenging because of their deep, neurovascularly crowded location and multicompartment extension; hyperostosis and rigid dural attachment further narrow the corridor and increase the risk of lower cranial nerve morbidity, causing dysphagia and airway complications that may rarely require tracheostomy. This study aimed to describe a contemporary function-first workflow integrating compartment-based anatomy, venous sinus status, preoperative embolization, and continuous vagus nerve monitoring and its relation to clinically actionable recovery endpoints. METHODS: The authors retrospectively reviewed 26 consecutive patients who underwent primary surgery for jugular foramen meningiomas (2014-2025). Tumors were classified as intradural + intrajugular (IJ) or intradural + intrajugular + extracranial extension (IJE). Retrosigmoid, suprajugular, or transjugular approaches were selected by tumor extension and sigmoid-jugular venous status. Selective embolization and continuous vagus nerve monitoring were used when feasible. Outcomes included extubation timing, time to oral intake, 1-year swallowing/voice severity, extent of resection, and salvage stereotactic radiosurgery (SRS) for progression/regrowth. RESULTS: Twenty tumors were IJ and 6 were IJE. Selective embolization was performed in 16 patients (62%) without complications. Continuous vagus nerve monitoring was implemented in 16 patients (62%); lower preservation rates showed an exploratory association with worse 1-year swallowing. All patients were extubated immediately after surgery. Oral intake began by postoperative day ≤ 7 in 20 patients (77%); only 1 required > 14 days before resuming oral intake. At 1 year, swallowing and hoarseness remained worse in 54% and 46% of patients, respectively, but almost all cases were mild; the same patient had moderate dysphagia/hoarseness, and none required tracheostomy, gastrostomy, long-term tube feeding, or phonosurgery. Simpson grade IV comprised 69% of cases but predominantly reflected intrajugular/extracranial residual rather than persistent intradural disease. No patient without preoperative facial nerve palsy developed new palsy; serviceable hearing was preserved in 70%, and 38% with preoperative nonserviceable hearing improved to serviceable hearing. During a median 55.6-month follow-up, 3 patients (12%) underwent salvage SRS for regrowth; none required reoperation. CONCLUSIONS: A function-first workflow guided by anatomical compartment extension and intraoperative monitoring can support rapid recovery and durable functional independence in jugular foramen meningiomas. The IJE phenotype identifies a higher-risk subgroup for delayed oral intake and postoperative subjective dysphagia/hoarseness, while continuous vagus nerve monitoring may provide actionable insights to calibrate surgical aggressiveness and support function-prioritized acceptance of intrajugular/extracranial residual with close surveillance and salvage SRS when needed.

Humans↗

PubMed2006

[Two cases of laryngoplasty performed under a general anesthesia applied using a laryngeal mask for the treatment of unilateral vocal cord paralysis].

In general, laryngoplasty for unilateral vocal cord paralysis is performed under local anesthesia because the patient's voice must be heard and the movement of the vocal cords visualized during the endoscopic procedure to ensure good results. We encountered two cases who could not endure a long operation under local anesthesia and the insertion of an endoscope because of their age and gag reflex. We thus performed a combined lateral cricoarytenoid muscle pull (LCA-pull) and a type I thyroplasty under general anesthesia applied using a laryngeal mask. Although the patients could not phonate during the operation, the laryngeal mask allowed the vocal cords to be observed. Both patients achieved in maximal phonation time over 13 seconds, and the postoperative mean flow rates improved to under 110 mL/s. The postoperative period perturbation quotient and amplitude perturbation quotient also improved to within the normal limits.

Aged, 80 and over↗

PubMed2006

[A combination study of S-1 and docetaxel in patients with head and neck cancer].

We determined the maximum tolerated dose (MTD), dose-limiting toxicity (DLT), and efficacy of drug sequence on toxicities of the combination of S-1 and docetaxel for head and neck cancers. S-1 was administered at the full dose of 80 mg/m2 for two weeks and docetaxel on day 1 according to the following dose escalation schedule: level 1: 40 mg/m2, level 2: 50 mg/m2, and level 3: 60 mg/m2. DLT was observed in two cases of level 3. Although grade 3 leukopenia was observed in level 3, all of the toxicities were not severe. Recommended doses for the next phase evaluation were determined to be 80 mg/m2 of S-1 and 50 mg/m2 of docetaxel. Oral S-1 combination with docetaxel is a feasible and promising combination regimen that is appropriate for an outpatient setting.

Administration, Oral↗

PubMed2005

Pleomorphic adenoma of the external auditory canal complicated by hearing loss secondary to chronic otitis media.

Pleomorphic adenoma (PA) rarely occurs in the external auditory canal (EAC). A case of PA complicated with chronic otitis media is reported. The patient was a 36-year-old male who began to experience a hearing loss in the left ear in 1996. He sought medical attention only after ear pain developed in April 2003. At the initial examination, a tumor covered by smooth skin was seen filling the left EAC. Pure-tone audiometry showed residual hearing at low frequencies and scale-out across middle to high frequency range. The CT and MRI findings led to a diagnosis of a tumor of the left EAC complicated with an inflammatory middle-ear lesion. The tumor was excised en bloc with the overlying skin, and tympanoplasty was performed. The pathological diagnosis was PA of the left EAC and inflammatory granuloma of the middle ear.

Adenoma, Pleomorphic↗

PubMed2005

A case of high-pitched diplophonia that resolved after a direct pull of the lateral cricoarytenoid muscle.

Various approaches have been employed for the surgical treatment of unilateral vocal cord paralysis. Recently, we performed a direct pull of the lateral cricoarytenoid muscle in a case of high-pitched diplophonia with little difference between the right and left vocal cord levels and obtained favorable results. The patient was a 66-year-old male who consulted our hospital with chief complaints of husky voice and abnormal sensation in the pharyngolaryngeal region. Cerebellum/brainstem inflammation was diagnosed in February 2002 and appropriate treatment was instituted. Despite an improvement in the patient's systemic condition, right vocal cord paralysis remained. Although there were no abnormalities in the vocal range for ordinary speech, diplophonia was noted at high pitches, and synchronization could not be observed using stroboscopy. Therefore, the patient was operated on in October 2002. The high-pitched diplophonia disappeared and stroboscopy revealed favorable mucosal waves at high pitches. Thus, direct pulling of the lateral cricoarytenoid muscle appears to be a useful procedure, even in a case of mild unilateral vocal cord paralysis.

Aged↗

PubMed2005

Direct pull of lateral cricoarytenoid muscle for unilateral vocal cord paralysis.

CONCLUSION: Lateral cricoarytenoid muscle-pull surgery (LCA pull) is a safe and effective method for the treatment of unilateral vocal cord paralysis. OBJECTIVE: To evaluate the results of an improved method of LCA pull for unilateral vocal cord paralysis. MATERIAL AND METHODS: Thirteen patients with unilateral vocal cord paralysis underwent LCA pull between April 2003 and January 2004. A small window was made in the posterior lower part of the thyroid cartilage and 2-3 mm in a cranial direction to the lower edge of the thyroid cartilage. The inner perichondrium was carefully removed to expose the LCA muscle. A 4-0 nylon suture placed through the LCA muscle was pulled to adduct the arytenoid and was tied to the anterior lower part of the thyroid cartilage. All cases were treated by LCA pull alone. In all cases, the maximum phonation time was measured and an auditory evaluation was performed using the grade, roughness, breathiness, asthenia and strain scale. The airflow rate was measured in five cases. RESULTS: Vocal improvement was obtained in 11/13 cases (85%). One of the unimproved cases had cricoarytenoid joint ankylosis. No complications were observed.

Adult↗