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Biomedical subjects

Konstantinos A Charalabopoulos

Publications and source records attributed to Konstantinos A Charalabopoulos.

6 recordsLinked to original sources
PubMed2006

Penile erection during transurethral surgery.

Intraoperative penile erection during endoscopic surgery, although an infrequent occurrence, is a troublesome complication and a challenge to the urologist. It is difficult to perform the procedure during penile erection, because various complications may occur. The etiology is unclear, and a number of pharmacological remedies have been discussed in the literature. Herein, we describe the treatment and outcomes for 3 patients with intraoperative penile erection and provide a brief review of the associated literature. Intraoperative penile erection is a rare event during transurethral procedures, with a frequency of approximately 0.1% in our institution. To our knowledge, no generally accepted protocols for the prevention or treatment of this phenomenon have been reported in the literature. We recommend intracorporeal injection of 250 microg of phenylephrine: detumescence occurred rapidly in all patients after a single injection. The mode of administration is simple, and no complications have been reported.

Adult↗
PubMed2006

Changes in breathing control and mechanics after laparoscopic vs open cholecystectomy.

HYPOTHESIS: We hypothesized that there might be different effects on breathing control and respiratory mechanics after laparoscopic vs open cholecystectomy. DESIGN: Randomized clinical trial. SETTING: A general hospital in Greece. PATIENTS: Of 53 patients assessed for eligibility, 18 and 10 were randomly allocated to the laparoscopic and open cholecystectomy groups, respectively. These 28 patients had normal spirometry measurements and American Society of Anesthesiologists' class I physical status. MAIN OUTCOME MEASURES: Measurements of breathing control and mechanics variables. Tidal volume, inspiratory time, breathing frequency, mean inspiratory flow, duty cycle, central respiratory drive, and mean inspiratory impedance were recorded before surgery on the second and eighth postoperative days. Airway resistance was recorded before surgery and on the eighth postoperative day, with all measurements being performed under no influence of analgesia. RESULTS: Two days after surgery, inspiratory time, breathing frequency, and central respiratory drive were significantly changed compared with preoperative values for both methods, whereas mean inspiratory impedance was significantly increased (P<.001) for the laparoscopic procedure. Eight days after surgery, changes were seen only for the laparoscopic group: duty cycle and airway resistance were significantly reduced (P = .01) and increased (P = .04), respectively, compared with preoperative data. CONCLUSION: Laparoscopic cholecystectomy seems to be associated with small but sustained alterations in the control of breathing and mechanics, which might have an unfavorable clinical impact on patients with compromised lung function.

Adult↗
PubMed2006

Pericardial involvement as an atypical manifestation of giant cell arteritis: report of a clinical case and literature review.

PURPOSE: Pericardial effusion has been known to be a rare manifestation of giant cell arteritis. During the last six decades, only 24 cases have been cited in the literature. In this report, we describe the case of a patient presenting with nonspecific symptoms and development of pericardial effusion. PROCEDURES AND FINDINGS: A 71-year-old woman was admitted to the hospital with low-grade fever, exertion breathlessness, atypical diffuse muscular pain, and weight loss over a period of about 5 weeks. Pericardial effusion and giant cell arteritis were diagnosed by echocardiography and left temporal artery biopsy, respectively. Treatment with corticosteroids resulted in remarkable improvement of symptoms and complete remission of pericardial effusion. One year after admission, the patient remained in a stable good condition, under low steroid maintenance dosage. CONCLUSIONS: The diversity of clinical manifestations (such as pericardial effusion) in such a potentially severe disease should alert the physician to prompt diagnosis and treatment in view of impending irreparable vascular damages, even in cases in which the initial presentation is quite uncommon.

Adrenal Cortex Hormones↗
PubMed2006

Ectopic modified sebaceous glands in human penis.

The balanopreputial sulcus is believed to be the most frequent site of the so-called Tyson's glands. The intriguing feature of these anatomical structures is their mere existence, which has been doubted. Herein, the authors present a case of a 24-year-old man who underwent surgical treatment of his phimosis. On microscopic examination of the specimen, glands with morphological features similar to those described by Tyson were noted.

Adult↗
PubMed2005

The art of science: transitional cell carcinoma of the bladder and Golconda.

Science and art are, surprisingly, intimately linked to each other. Over the centuries, artists used their talent in order to depict with the greatest detail possible the human anatomy and later the histology of tissues, helping scientists comprehend better the world and human nature. From the opposite perspective, scientific images coming from observation or experimentation can constitute art since they can have form and beauty. An example is mitotic figures, particularly the atypical ones observed in cancer. The affinity between art and science is demonstrated herein, by their harmonic coexistence in one figure, and also by the ease and naturalness by which the phrases used by Magritte in order to describe one of his paintings, the famous "Golconda" can be paraphrased to describe a neoplasm, a transitional cell carcinoma of the bladder.

Art↗