Biomedical subjects

Koorosh Moezardalan

Publications and source records attributed to Koorosh Moezardalan.

4 recordsLinked to original sources

PubMed2006

H. pylori infection and reflux oesophagitis: a case-control study.

AIM: To examine the relationship between H. pylori and gastro-oesophageal reflux disease (GORD) in Iran. METHODS: In this study 51 GORD patients (referred to endoscopy at Taleghani hospital) were compared with 49 age-sex matched controls. Diagnosis of H. pylori was made by gastric mucosal biopsy and rapid urease test (positive if the result of one or both diagnostic methods was positive). Updated Sydney system was used to report histopathological changes. RESULTS: The frequency of H. pylori infection based on rapid urease test and histology was 88.2% (45) in patients and 77.6% (38) in controls, which showed no significant difference. The frequency of H. pylori infection was significantly higher in the antrum than in the corpus and cardia. The mean activity, inflammation, and gastritis scores were also higher in the antrum of patients than in the antrum of controls. The mean scores were significantly higher in the corpus of controls than in the corpus of patients. Diffuse active gastritis was observed in a significantly larger number of controls, while the frequency of diffuse chronic gastritis was higher in patients. There was no significant difference in the frequency of other histological findings between patients and controls. CONCLUSION: H. pylori infection cannot prevent GORD in this region.

Adolescent↗

PubMed2005

The utility and the safety of EUS-guided FNA in the evaluation of duplication cysts.

BACKGROUND: Diagnosis of a foregut duplication cyst is of great clinical impact. A definitive diagnosis of a foregut duplication cyst can avert the need for major thoracic surgery in the otherwise asymptomatic individual. This study sought to evaluate the safety and the utility of EUS and EUS-guided FNA (EUS-FNA) in the diagnosis of foregut duplication cysts. METHODS: Over a period of 4 years, 4771 patients underwent EUS for various indications at two EUS referral centers. EUS findings were consistent with a mediastinal cyst in 30 cases. EUS-FNA was performed in 22 patients. A definitive diagnosis was established based on cytology, surgical pathology, and/or clinical follow-up. FNA was done with 22-gauge needles and antibiotic prophylaxis. RESULTS: The appearance of cyst contents on EUS ranged from completely anechoic (23 cases) to hypoechoic (7 cases). Hypoechoic cystic lesions contained echogenic foci. All anechoic lesions were confirmed as benign duplication cysts based on cytology, pathology, and clinical follow-up. Hypoechoic cystic lesions were confirmed to be benign duplication cysts in 4 cases. Three cases proved to be malignant or granulomatous necrotizing lymph nodes. No periprocedural complications occurred. CONCLUSIONS: Variation exists in the EUS appearance of benign mediastinal cysts. EUS-FNA of mediastinal cysts with smaller-gauge needles, and antibiotic prophylaxis appears safe and can provide a definitive diagnosis in atypical mediastinal cystic lesions.

Adult↗

PubMed2005

Comparing logistic models based on modified GCS motor component with other prognostic tools in prediction of mortality: results of study in 7226 trauma patients.

A simple reproducible and sensitive prognostic trauma tool is still needed. In this article we have introduced modified GCS motor response (MGMR) and evaluated the performance of logistic models based on this variable. The records of 8452 trauma patients admitted to major hospitals of Tehran from 1999 to 2000 were analysed. 7226 records with known outcome were included in our study. Logistic models based on outcome (death versus survival) as a dependent variable and Injury Severity Score (ISS), Revised Trauma Score (RTS), Glasgow Coma Scale (GCS), GCS motor component (GMR) and MGMR (following command [=2], movement but not following [=1] command and without movement [=0]) were compared based on their accuracy and area under the Receiver Operating Characteristic (ROC) curve. The accuracy of the Trauma and Injury Severity Score (TRISS), RTS, GCS, GMR and MGMR models were almost the same. Considering both the area under the ROC curve and accuracy, the age included MGMR model was also comparable with other age included models (RTS+age, GCS+age, GMR+age). We concluded that although in some situations we need more sophisticated models, should our results be reproducible in other populations, MGMR (with or without age added) model may be of considerable practical value.

Adolescent↗

PubMed2004

Aeromonas spp associated with children's diarrhoea in Tehran: a case-control study.

The study sought a possible pathogenic role for Aeromonas spp in Tehranian children presenting with diarrhoea. During a 10-month period (February to October 2001), 310 children <10 years of age with diarrhoea and a group of 310 age- and sex-matched controls were selected. Both groups were investigated for diarrhoeal pathogens. Of 310 children who presented with acute diarrhoea, Aeromonas spp was isolated from 14 (4.5%) (A. veronii biovar sobria 8, A. caviae 5 and A. hydrophila 1). The isolation rate was significantly higher than in the controls (p<0.001). Other enteropathogens were also more commonly isolated in children with diarrhoea: 57 (18.4%) Shigella spp (p<0.0001), 8 (2.6%) Salmonella spp (p<0.01), 7 (2.3%) enteropathogenic E. coli (p<0.05) and 8 (2.6%) Giardia lamblia (p<0.01). No enteropathogens were isolated in the control group. Dysentery was the dominant clinical feature in children positive for Aeromonas spp.

Acute Disease↗