Biomedical subjects

Kristie L Cooper

Publications and source records attributed to Kristie L Cooper.

4 recordsLinked to original sources

PubMed2006

All-fused-silica miniature optical fiber tip pressure sensor.

An all-fused-silica pressure sensor fabricated directly onto a fiber tip of 125 microm diameter is described. Simple fabrication steps include only cleaving and fusion splicing. Because no chemical processes are involved, the fabrication is easy, safe, and cost effective. Issues in sensor design and loss analysis are discussed. The sensor has been tested for static pressure response, showing a sensitivity of 2.2 nm/psi, a resolution of 0.01 psi (68.9 Pa), a hysteresis of 0.025%, and capability of operation at temperatures up to 600 deegrees C. This miniature sensor may be suitable for medical diagnostics, environmental monitoring, and other industrial applications.

Journal Article↗

PubMed2005

Miniature all-silica fiber optic pressure and acoustic sensors.

We present a miniature diaphragm-based Fabry-Perot (F-P) interferometric fiber optic sensor fabricated by novel techniques for pressure or acoustic wave measurement that is only approximately 0.32 mm in diameter. By choosing different diaphragm thicknesses and effective diameters, we obtain a sensor measurement range from 5 to 10,000 psi (1 psi = 51.72 Torr) and a frequency response up to 2 MHz. In addition, the sensor's F-P cavity can be set from micrometers to millimeters with a precision of several nanometers. With the all-silica structure, the sensor is reliable, biocompatible, and immune to electromagnetic interference and has high-temperature sensing capability.

Journal Article↗

PubMed2005

In-fiber reflection mode interferometer based on a long-period grating for external refractive-index measurement.

We present two novel schemes for refractometry based on a long-period fiber grating- (LPG-) based Michelson interferometer. These schemes are designed to overcome the measurement dependence of previously demonstrated LPG-based refractometry on the immersion depth. The first utilizes an unshielded LPG and the second, a shielded one. Both schemes were tested over a certain refractive-index range, and the measurement of glucose concentration in water was experimentally demonstrated. In addition, the temperature sensitivity of the two schemes is discussed.

Journal Article↗

PubMed2005

Miniature fiber-optic multicavity Fabry-Perot interferometric biosensor.

A fiber-optic sensor is designed based on multicavity Fabry-Perot interferometry for the study of optical thickness in self-assembled thin-film layers. This miniature sensor is applicable not only to the measurement of self-assembled polyelectrolyte layers but also to the immobilization of proteins such as immunoglobulin G (IgG). The binding of IgG and the corresponding antigen is observed, and the nonspecific binding characteristics are investigated. The optical thickness changes are used to evaluate the immobilization of the IgG and the immunological activities of the immobilized layers.

Biosensing Techniques↗