Biomedical subjects

Kristopher J Preacher

Publications and source records attributed to Kristopher J Preacher.

4 recordsLinked to original sources

PubMed2003

Chronic stress and age-related increases in the proinflammatory cytokine IL-6.

Overproduction of IL-6, a proinflammatory cytokine, is associated with a spectrum of age-related conditions including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes, certain cancers, periodontal disease, frailty, and functional decline. To describe the pattern of change in IL-6 over 6 years among older adults undergoing a chronic stressor, this longitudinal community study assessed the relationship between chronic stress and IL-6 production in 119 men and women who were caregiving for a spouse with dementia and 106 noncaregivers, with a mean age at study entry of 70.58 (SD = 8.03) for the full sample. On entry into this portion of the longitudinal study, 28 of the caregivers' spouses had already died, and an additional 50 of the 119 spouses died during the 6 years of this study. Levels of IL-6 and health behaviors associated with IL-6 were measured across 6 years. Caregivers' average rate of increase in IL-6 was about four times as large as that of noncaregivers. Moreover, the mean annual changes in IL-6 among former caregivers did not differ from that of current caregivers even several years after the death of the impaired spouse. There were no systematic group differences in chronic health problems, medications, or health-relevant behaviors that might have accounted for caregivers' steeper IL-6 slope. These data provide evidence of a key mechanism through which chronic stressors may accelerate risk of a host of age-related diseases by prematurely aging the immune response.

Aged↗

PubMed2002

Exploratory factor analysis in behavior genetics research: factor recovery with small sample sizes.

Results of a Monte Carlo study of exploratory factor analysis demonstrate that in studies characterized by low sample sizes the population factor structure can be adequately recovered if communalities are high, model error is low, and few factors are retained. These are conditions likely to be encountered in behavior genetics research involving mean scores obtained from sets of inbred strains. Such studies are often characterized by a large number of measured variables relative to the number of strains used, highly reliable data, and high levels of communality. This combination of characteristics has special consequences for conducting factor analysis and interpreting results. Given that limitations on sample size are often unavoidable, it is recommended that researchers limit the number of expected factors as much as possible.

Animals↗

PubMed2002

On the practice of dichotomization of quantitative variables.

The authors examine the practice of dichotomization of quantitative measures, wherein relationships among variables are examined after 1 or more variables have been converted to dichotomous variables by splitting the sample at some point on the scale(s) of measurement. A common form of dichotomization is the median split, where the independent variable is split at the median to form high and low groups, which are then compared with respect to their means on the dependent variable. The consequences of dichotomization for measurement and statistical analyses are illustrated and discussed. The use of dichotomization in practice is described, and justifications that are offered for such usage are examined. The authors present the case that dichotomization is rarely defensible and often will yield misleading results.

Humans↗

PubMed2002

Comments on the Meehl-Waller (2002) procedure for appraisal of path analysis models.

P. E. Meehl and N. G. Waller (2002) proposed an innovative method for assessing path analysis models wherein they subjected a given model, along with a set of alternatives, to risky tests using selected elements of a sample correlation matrix. Although the authors find much common ground with the perspective underlying the Meehl-Waller approach, they suggest that there are aspects of the proposed procedure that require close examination and further development. These include the selection of only one subset of correlations to estimate parameters when multiple solutions are generally available, the fact that the risky tests may test only a subset of parameters rather than the full model of interest, and the potential for different results to be obtained from analysis of equivalent models.

Humans↗