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Biomedical subjects

Krzysztof Rutkowski

Publications and source records attributed to Krzysztof Rutkowski.

6 recordsLinked to original sources
PubMed2006

[CD28 and CTLA-4 costimulatory molecules expression on T lymphocytes and NK cells in nonallergic bronchial asthma].

UNLABELLED: The aim of the study was to assess the role of costimulatory molecules in pathogenesis of nonallergic bronchial asthma. MATERIAL: The studied group consisted of 30 patients with nonallergic asthma, 24 with nonallergic asthma and recurrent respiratory tract infections and 20 healthy controls. RESULTS: In nonstimulated and lipopolysaccharide (LPS) stimulated cultures of control group the mean value of CD16+ + 56+ CD28+ subpopulation were significantly decreased compared to values in both types of asthma. Similar dependence was observed in cultures of asthmatic patients with infection and healthy person, stimulated with IL-15 and in CD4+CD28+, CD8 +CD28+ and NKCD28+ cultures from all studied groups, stimulated with LPS plus IL-15. In nonallergic asthma and infection asthma mean values of CD4 +CD152+ and CD16+ +CD56 +CD152+ from nonstimulated and IL-15 stimulated cultures were significantly increased compared to analogical values in control group. CONCLUSION: The results of our studies suggest that in nonallergic asthma the disturbed expression of costimulatory molecules may play an important role in pathomechanism of disease.

Adrenergic beta-Agonists↗
PubMed2005

[Vocal cord dysfunction or bronchial asthma?].

Vocal cord dysfunction (VCD) is a functional laryngeal dysfunction first described in the nineteenth century. It is quite frequent in patients with "refractory" asthma. It is very often treated as a steroid resistant asthma or exercise-induced bronchospasm, leading to unnecessary, aggressive asthma treatment and iatrogenic morbidity. Vocal cord dysfunction causes paradoxical adduction of vocal cords during the inspiratory phase of respiratory cycle, resulting in acute, episodic dyspnea not responding to typical antiasthmatic treatment. Laryngoscopy remains a gold standard for the diagnosis of vocal cord dysfunction. Additional pulmonary function tests may be useful. Fast and appropriate diagnosis of VCD is only possible with close collaboration of laryngologists and asthma specialists. The treatment of dyspnea attack in VCD involves psychological counseling, heliox application and sedative/anxiolytic agents. Long term treatment may include speech therapy, biofeedback, yoga and autohypnosis.

Asthma↗
PubMed2005

[Methods of expired nitric oxide assessment in pulmonary diseases in children].

Assessment of exhaled nitric oxide (eNO) creates new diagnostic possibilities for evaluation of the inflammatory process especially in children, in whom not all of the contemporary methods of diagnosing respiratory tract diseases are applicable. eNO concentration can be measured in children of all age, including neonates. Direct assessment of eNO is possible with an on-line method, in which NO is directly exhaled into a chemiluminescence analyser. An off-line method is performed by exhalation into a collapsible bag of nonreacting material and analysing the collected air with appropriate analysers. eNO measurement is a non-invasive, repeatable, rapid and sensitive method, producing results even during measurement. Assessment of eNO in children may be used to quantify inflammation in asthma and other respiratory tract diseases specific for this age group. Monitoring of the therapy and response to the anti-inflammatory agents i.e. glucocorticosteroids and anti-leukotriene drugs can also be based on eNO measurement.

Breath Tests↗
PubMed2003

CD80 and CD86 expression on LPS-stimulated monocytes and the effect of CD80 and CD86 blockade on IL-4 and IFN-gamma production in nonatopic bronchial asthma.

CD80 and CD86 seem to play an important role in the allergen-induced secretion of interleukin (IL)-5 and IL-13. Up to now, the expressions of CD80 (B7.1) and CD86 (B7.2) on monocytes and the kinetics of the expression of these molecules on lipopolysaccharide-stimulated monocytes in nonatopic asthma have not been defined. Using monoclonal antibodies, we have compared the expressions of CD80 (B7.1) and CD86 (B7.2) on the monocytes of healthy persons and nonatopic asthmatic patients. We have also assessed the effect of CD80 and CD86 inactivation on IL-4 and interferon (IFN)-gamma production in nonatopic asthmatics and healthy subjects. We found that a low expression of CD80 (1.64 +/- 0.65 vs. 3.53 +/- 1.43%) and a moderate expression of CD86 (41.25 +/- 13.4 vs. 49.46 +/- 11.49%) on the studied monocytes were characteristic for asthma. In nonatopic asthma patients inactivation of CD80 or CD86 blockade significantly reduced IFN-gamma production by T lymphocytes (p < 0.02; p < 0.03). In both the studied groups, anti-CD80 antibodies did not diminish T lymphocyte production of IL-4. However, anti-CD86 antibodies significantly (p < 0.04) reduced the IL-4 concentration in culture supernatants. Our results confirm that both the CD80 and CD86 molecules play an important role in the maintenance and amplification of the inflammatory process. It suggests that in the inflammatory process that occurs in nonatopic bronchial asthma, Th1 as well as Th2 lymphocytes are equally important.

Adult↗
PubMedDate not supplied

[Comparative diagnosis of posttraumatic disorders].

In the article, clinical symptoms of disorders presently considered posttraumatic have been comprised. Apart from PTSD and ASD they constitute personality changes, chronic and brief psychotic disorders and depression. Most disorders were described from the perspective of ICD and DSM criteria. The analysis of classic (KZ-Syndrome) and postulated disorders (COMPLEX PTSD) were added as well as the most frequently misinterpreted ones, that is adaptation disorders in ICD, with the reactions to trauma. The article was completed with a questionnaire which helps the researchers verify the diagnosis and differentiate between PTSD, ASD and a permanent personality change. The questionnaire may be a convenient way to estimate the number of symptoms and their descriptions for the consultation and certification purposes.

Diagnosis, Differential↗