Acute pulmonary injury due to exposure to a high concentration of trichloroethylene vapor.
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Adult↗
Biomedical subjects
Kunio Hara
Publications and source records attributed to Kunio Hara.
A new double-bundle anterior cruciate ligament reconstruction using the posteromedial portal technique with hamstrings.
We describe a new double-bundle reconstruction method for ruptured anterior cruciate ligament using a posteromedial portal technique. Reconstruction materials are semitendinosus tendon (STT) and gracilis tendon (GT). STT is used as the substitute for the anteromedial bundle (AMB) and fixed to the tunnels produced on the tibia and the femur. GT is used as the substitute for the posterolateral bundle (PLB) and fixed to the tunnels on the tibia and the femur. This femoral tunnel for the PLB is created through a posteromedial portal. These procedures are performed using the inside-out technique. The posteromedial portal provides an accurate access to the femoral attachment of the PLB. This surgical technique can avoid overlapping of the 2 femoral tunnels and destruction of the posterior cortex of the lateral condyle on the femur during the preparation of the PLB. Our technique does not need another tibial tunnel for the PLB; the 1 tibial tunnel enables double-bundle reconstruction and prevents tibial tunnel expansion.
Anterior Cruciate Ligament↗
Cytochrome P450 1B1 mRNA levels in peripheral blood cells and exposure to polycyclic aromatic hydrocarbons in Chinese coke oven workers.
Cytochrome P450 1B1 (CYP1B1) is induced through the Ah receptor and is involved in the activation of polycyclic aromatic hydrocarbons (PAHs). To determine the validity of a quantitative analysis of CYP1B1 mRNA in peripheral human blood cells for the estimation of PAH exposure, a real-time quantitative polymerase chain reaction method was used to measure the relative levels of CYP1B1 mRNA in 37 Chinese coke oven workers and 13 control workers. A large inter-individual difference in the levels was observed. The average level of the CYP1B1 mRNA in workers at the top work site, where the PAH exposure level from the coke ovens was highest, was significantly higher than in workers at the middle site (P<0.01) or the controls (P=0.02). A non-significant positive correlation was found between the CYP1B1 mRNA levels and urinary 1-hydroxypyrene (R=0.22, P=0.13), and a significant correlation between these mRNA levels and urinary cotinine (R=0.33, P=0.02). It was interesting that a significant positive correlation between CYP1B1 mRNA and 1-hydroxypyrene was observed in subjects with the Leu/Leu type of CYP1B1 Leu432Val polymorphism (R=0.33, P=0.02, n=38) and a non-significant correlation in subjects with the Leu/Val and Val/Val types (R=-0.36, P=0.25, n=12), although the number of subjects in this strata analysis was small. Our preliminary study suggests that PAH exposure in coke ovens and smoking maybe associated with CYP1B1 mRNA levels in peripheral blood cells although mRNA is generally unstable and could be expressed following exposure to other agents.
Adult↗
Anterior cruciate ligament reconstruction using the double bundle method.
Clinical results of our reconstruction technique for anterior cruciate ligament using the double bundle, i.e., the combination of bone-tendon-bone (BTB) from the patellar tendon and semitendinosus tendon (ST), were evaluated. BTB was fixed in the tunnels produced on the isometric points on the tibia and femur, and ST, on the tibial tunnel through the same route as BTB. Throughout the observation period, no patients developed pain, limited range of motion, and/or instability of the operated knee. All patients were able to return to previous sports activities within 12 months. No apparent changes occurred on the reconstructed ligament. In 4 of 14 patients, knee stability was quantitatively examined, and a good result was obtained. The double bundle was found to be a useful method for patients who require physiologically more durable reconstruction.
Journal Article↗