Kurt F Seefeldt | PubMed Health

PubMed2003

Self-diffusion in dilute colloidal suspensions with attractive potential interactions.

The colloidal short-time self-diffusivity D(s)(s)(phi) is significantly retarded relative to hard sphere suspensions for the case of interparticle potential interactions induced by a nonadsorbing polymer. A comparison of diffusing wave spectroscopy measurements with direct calculations of D(s)(s)(phi) demonstrates that depletion effects on structure explain the observed retardation. We show that coexistence boundaries place unexpectedly severe constraints on the amount of D(s)(s)(phi) retardation possible for stable suspensions. The measured retardation is demonstrated to be an indicator of suspension metastability.

Journal Article↗

PubMedDate not supplied

Reaction crystallization of pharmaceutical molecular complexes.

A mechanism for cocrystal synthesis is reported whereby nucleation and growth of cocrystals are directed by the effect of the cocrystal components on reducing the solubility of the molecular complex to be crystallized. The carbamazepine:nicotinamide cocrystal (CBZ:NCT) was chosen as a model system to study the reaction cocrystallization pathways and kinetics in aqueous and organic solvents. Fiber optic Raman spectroscopy and Raman microscopy were used for in situ monitoring of the cocrystallization in macroscopic and microscopic scales in solutions, suspensions, slurries, and wet solid phases of cocrystal components. This study demonstrates the advantages of reaction cocrystallization methods to develop rational approaches for high-throughput screening of cocrystals that can be transferable to control batch and continuous cocrystallization processes.

Crystallization↗