Hepatitis E virus in cultivated cells.
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Animals↗
Biomedical subjects
Kusov YuYu
Publications and source records attributed to Kusov YuYu.
Immunogenicity trial of inactivated hepatitis A virus vaccine in human volunteers.
An inactivated hepatitis A virus (HAV) vaccine was tested on a group of human adult volunteers. The vaccine was administered subcutaneously, and a control group received a placebo (aluminium hydroxide). The vaccine was found to be relatively well tolerated and non-reactogenic, and levels of anti-HAV were comparable to those in other studies.
Adolescent↗
Characteristics of inactivated hepatitis A vaccine prepared from virus propagated in heteroploid continuous monkey cell line.
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Animals↗
Variations in genome fragments coding for RNA polymerase in human and simian hepatitis A viruses.
The genome of hepatitis A virus (HAV) isolated from spontaneously infected African vervet monkey (Cercopithecus aethiops) has been cloned and partially sequenced. Comparison of genome fragments (1248 and 162 bp) from the 3D (RNA polymerase) region with the corresponding parts of human HAV genomes revealed a high degree of heterogeneity: there were altogether 257 nucleotide changes leading to 44 substitutions in predicted amino acid sequence, i.e. 89% amino acid identity. This divergence is considered to be significantly greater than genomic variations usually found among human HAV strains, where amino acid identity in the 3D region is over 98%.
Amino Acid Sequence↗