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Kwan Lee

Publications and source records attributed to Kwan Lee.

5 recordsLinked to original sources
PubMed2005

[Epidemiologic investigation on an outbreak of shigellosis in Seongju-gun, Korea, 2003].

OBJECTIVES: An outbreak of shigellosis occurred among students and staff of S primary and middle school, Seongju-gun, in 2003. This investigation was carried out to institute an effective counterplan, and study the infection source and transmission of the shigellosis. METHODS: The authors conducted a questionnaire survey among 235 students and staff from S preschool, primary and middle school relating to the ingestion of school lunch and the manifestation of symptoms. Also, the author investigated the drinking water, feeding facility and reconstructed cooking process of the food presumed to be the cause of the shigellosis. The diarrhea cases were defined as confirmed cases and those cases who had had diarrhea more than one time, accompanied with symptoms such as fever, vomiting and tenesmus. RESULTS: From rectal swabs 20 people, between June 28 and July 4, 2003, were confirmed with shigellosis. The diarrhea attack rate was 40.0%. Those who had ingested tomatoes and cubed radish kimchi had significantly higher diarrhea attack rates (p<0.05), with the relative risk of tomatoes being 2.69 (95% CI: 0.98-7.42). The major cause of shigellosis was presumed to be from contaminated tomatoes due to cooking with rubber gloves containing holes. CONCLUSION: The cooks in charge of school lunches must make doubly sure to not only attend to their sanitation, but also to manage the table wear and items used in providing school lunches. The health care authority should introduce higher-leveled criteria for health care among cooks, so that they cannot cook when the have a case of any infectious disease.

Adolescent↗
PubMed2002

Using control charts to assess performance measurement data.

BACKGROUND: In 1997 the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) announced the ORYX initiative, which integrates outcomes and other performance measurement data into the accreditation process. JCAHO uses control and comparison charts to identify performance trends and patterns that are provided to JCAHO surveyors in advance of the organization's survey. During its survey, the health care organization (HCO) is asked to explain its rationale for its selection of performance measures, how the ORYX data have been analyzed and used to improve performance, and the outcomes of these activities. WHAT DO CONTROL CHARTS DO? Control charts indicate whether an HCO's process is in statistical control (that is, stable insofar as only common cause variation exists) or out of statistical control (that is, unstable insofar as special cause variation exists). With the presence of special cause variation, the HCO should not make any change in its processes until the special cause is identified and eliminated. CHOOSING THE CORRECT CONTROL CHART: An HCO can use many different control charts. Selecting the correct control chart type for the type of data collected makes interpretation more sensitive for detecting special cause variation. The ORYX measures are calculated as proportions (rates), ratios, and means (continuous variables data, such as average length of stay), and this information forms the basis for selecting the correct type of control chart. In addition, the average rate (especially for rare event measures) and the average number of cases need to be considered when selecting the control chart type for small population measures.

Accidental Falls↗
PubMed2002

High-sensitivity hybridization assay for quantitation of residual E. coli DNA.

Impurity assays for recombinant protein therapeutics are essential to ensure batch-to-batch consistency and to meet the FDA's criteria for a well-characterized biopharmaceutical. For determination of residual host cell DNA, membrane hybridization assays utilizing radiolabeled DNA probes prepared from the host cell's genomic DNA have traditionally been used for products derivedfrom bacterial expression systems to obtain the required low picogram sensitivity. Nonradioactive methods, while desirable to eliminate radioactive waste disposal and safety issues, typically suffer from poor sensitivity and high backgrounds. We report the development of a suitably sensitive, nonradioactive assay to quantitate residual E. coli DNA levels in purified protein drugs by means of a slot-blot hybridization method. The assay utilizes digoxigenin-labeled E. coli DNA probes and SuperSignal chemiluminescent substrate. The optimized chemiluminescent hybridization assay has both low background and high sensitivity, allowing routine detection of 2.5 pg E. coli DNA. The method can be tailored for detection/quantitation of DNA contamination in recombinant protein products expressed in E. coli or other bacterial expression systems.

Antibodies↗