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Biomedical subjects

Kyung W Park

Publications and source records attributed to Kyung W Park.

At least 19 recordsLinked to original sources
PubMed2006

Effects of ulinastatin on pulmonary artery pressure during abdominal aortic aneurysmectomy.

STUDY OBJECTIVE: Abdominal aortic aneurysmectomy (AAAectomy) results in a general ischemia-reperfusion syndrome accompanied by an acute rise in pulmonary artery pressure (PAP). We examined whether ulinastatin, a urinary trypsin inhibitor, prevents ischemia-reperfusion injury and increase in PAP after aortic unclamping (XU) during AAAectomy. DESIGN: Prospective study. SETTING: Public, university-affiliated hospital. PATIENTS: Sixteen patients (11 males and 5 females) scheduled for AAAectomy. INTERVENTIONS AND MEASUREMENTS: The patients received 300000 IU of ulinastatin intravenously before XU (n = 8) or no additional treatment (n = 8) (control). Heart rate, central venous pressure, PAP, pulmonary arterial wedge pressure, arterial pressure, mixed venous oxygen saturation (Sv(O2)), and cardiac output were monitored. Arterial and mixed venous blood samples were analyzed for pH, Pa(CO2), Pa(O2), hemoglobin, and oxygen saturation, and the physiological shunt function (Qs/Qt) were calculated. Plasma concentrations of malondialdehyde, myeloperoxidase, granulocyte elastase, alpha1-antitrypsine, and thromboxane B2 and the stable hydrolysis products of thromboxane A2 were measured. Measurements were conducted before aortic crossclamping (XC) (baseline) and at 10, 30, and 60 minutes after XU. MAIN RESULTS: A significant increase in PAP was observed 10 minutes after XU in the control group but not in the ulinastatin group. At 60 minutes after XU, Qs/Qt values had increased in the control group but had decreased in the ulinastatin group. There were no significant changes in malondialdehyde, thromboxane B2, granulocyte elastase, and alpha1-antitrypsine levels after XU in either group. A significant decrease in the plasma level of myeloperoxidase after XU was found in both groups. CONCLUSIONS: The present study demonstrated that ulinastatin prevents increase in PAP and shunting after XU during AAAectomy.

Aged↗
PubMed2006

Inadvertent placement of a flow-directed pulmonary artery catheter in the coronary sinus, detected by transesophageal echocardiography.

We report a case in which flow-directed placement of the pulmonary artery catheter led to its inadvertent placement in the coronary sinus, in the absence of congenital anomalies. Incorrect placement was diagnosed by use of the transesophageal echocardiography. If unrecognized, the catheter might have provided misleading information and led to mismanagement of the patient.

Aged, 80 and over↗
PubMed2005

Perioperative and long-term morbidity and mortality after above-knee and below-knee amputations in diabetics and nondiabetics.

We performed a retrospective review of a vascular surgery quality assurance database to evaluate the perioperative and long-term morbidity and mortality of above-knee amputations (AKA, n = 234) and below-knee amputations (BKA, n = 720) and to examine the effect of diabetes mellitus (DM) (181 of AKA and 606 of BKA patients). All patients in the database who had AKA or BKA from 1990 to May 2001 were included in the study. Perioperative 30-day cardiac morbidity and mortality and 3-yr and 10-yr mortality after AKA or BKA were assessed. The effect of DM on 30-day cardiac outcome was assessed by multivariate logistic regression and the effect on long-term survival was assessed by Cox regression analysis. The perioperative cardiac event rate (cardiac death or nonfatal myocardial infarction) was at least 6.8% after AKA and at most 3.6% after BKA. Median survival was significantly less after AKA (20 mo) than BKA (52 mo) (P < 0.001). DM was not a significant predictor of perioperative 30-day mortality (odds ratio, 0.76 [0.39-1.49]; P = 0.43) or 3-yr survival (Hazard ratio, 1.03 [0.86-1.24]; P = 0.72) but predicted 10-yr mortality (Hazard ratio, 1.34 [1.04-1.73]; P = 0.026). Significant predictors of the 30-day perioperative mortality were the site of amputation (odds ratio, 4.35 [2.56-7.14]; P < 0.001) and history of renal insufficiency (odds ratio, 2.15 [1.13-4.08]; P = 0.019). AKA should be triaged as a high-risk surgery while BKA is an intermediate-risk surgery. Long-term survival after AKA or BKA is poor, regardless of the presence of DM.

Adrenergic beta-Antagonists↗
PubMed2004

Preoperative cardiac evaluation.

The current standards for preoperative cardiac evaluation and the guidelines published by the American College of Cardiology and the American Heart Association call for noninvasive or invasive cardiac evaluation in certain patients. Perioperative use of beta-adrenergic blockade has been shown to reduce cardiac complication rates, diminishing the positive predictive value and the likelihood ratio of a positive result of a preoperative cardiac test,unfavorably shifting the risk to benefit ratio of preoperative tests and any possible therapeutic action that one might take based on the test. A new paradigm might be emerging that makes cardiac tests unnecessary except in the highest-risk patients identified by clinical variables.

Adrenergic beta-Antagonists↗
PubMed2003

Association of sex with perioperative mortality and morbidity after carotid endarterectomy for asymptomatic carotid stenosis.

OBJECTIVE: To examine whether perioperative morbidity and mortality after carotid endarterectomy depend on the sex and the presence of symptoms on presentation. DESIGN: Retrospective review of quality assurance database prospectively collected. SETTING: A university teaching hospital. PARTICIPANTS: One thousand two hundred eighty-seven patients who had 1,503 carotid endarterectomies from 1990 to 1999 from a quality assurance database. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The cases were divided into 4 groups by sex and symptoms on presentation: male-symptomatic (MS), male-asymptomatic (MA), female-symptomatic (FS), and female-asymptomatic (FA). The 4 groups were compared for preoperative demographic and comorbidity profiles, carotid plaque characteristics, and outcome. Outcome measures included in-hospital stroke, myocardial infarction (MI), congestive heart failure (CHF), and death. There were 496 cases in the MS group, 407 in the MA group, 315 in the FS group, and 285 in the FA group. Women were less likely to have a history of coronary artery disease, prior MI, or smoking, and their carotid plaques were less likely to be ulcerated or contain intraplaque hemorrhage. Even when controlling for the comorbidities and plaque characteristics, the incidence of each of the complications examined was low and not significantly different between the sexes in both the symptomatic and asymptomatic groups. The rate of stroke or death was 3.0% (MS) versus 1.9% (FS) (p = NS) and 1.2% (MA) versus 1.8% (FA) (p = NS). CONCLUSION: There is no significant sex difference in perioperative cardiac or cerebrovascular complications. Women with symptomatic or asymptomatic carotid stenosis can have acceptably low complication rates from carotid endarterectomy and may benefit from the surgery as much as men.

Aged↗
PubMed2003

Comparison of thermodilution bolus cardiac output and Doppler cardiac output in the early post-cardiopulmonary bypass period.

OBJECTIVE: To evaluate the accuracy of measuring cardiac output (CO) in the early post-cardiopulmonary bypass (CPB) period by comparing thermodilution with Doppler methods. DESIGN: Prospective and blinded human trial. SETTING: Academic medical center. PARTICIPANTS: Thirty adult patients undergoing elective coronary artery bypass graft surgery. MEASUREMENTS AND MAIN RESULTS: Thermodilution CO (TCO) was obtained in triplicate. Doppler CO (DCO) in triplicate was obtained at the left ventricular outflow tract (LVOT), aortic valve (AV), and right ventricular outflow tract (RVOT). CO measurements were made (1). before CPB (baseline), (2). immediately after CPB, (3).15 minutes after CPB, and (4). 30 minutes after CPB. Before CPB, the DCO at LVOT, RVOT, and AV showed good correlations (r = 0.87, r = 0.88, and r = 0.84, respectively) with TCO. Bias analysis showed no significant difference among TCO and 3 DCOs (p > 0.05 each). Correlation between DCO and TCO decreased but remained significant after CPB (r between 0.57 and 0.85, p < 0.001). The bias among TCO and each of the DCOs at the LVOT, RVOT, and AV increased immediately after CPB (p < 0.01, p < 0.01, and p < 0.05, respectively) and remained significant at 15 minutes and 30 minutes post-CPB except for DCO at the AV. TCO exceeded DCO by 0.44 to 0.72 L/min immediately after CPB. The CO measured by both thermodilution and Doppler methods gradually decreased over time post-CPB. The decrease in CO was significant at 30 minutes post-CPB (p < 0.01). CONCLUSION: This study adds further support that DCO is a clinically acceptable method to accurately assess the CO in patients even during periods of uneven regional body temperatures as may occur in the early post-CPB period.

Aged↗