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Biomedical subjects

L A Alipchenko

Publications and source records attributed to L A Alipchenko.

At least 19 recordsLinked to original sources
PubMed2000

[Role of induction chemo- and radiotherapy in the treatment of locally advance breast cancer].

336 patients with locally-advanced breast cancer underwent neoadjuvant chemotherapy or chemoradiotherapy. Increase in T- and N-indices (change of stage after neoadjuvant chemotherapy) proved an important prognostic factor. Survival rates correlated with clinical effect and dropped as it diminished. This tendency was clear in both groups. There was no relationship between stage and overall and disease-free survival rates at early stages but later they declined as T- and N-indices decreased.

Adult↗
PubMed1992

[The degree of tumor vascularization as a prognostic factor of the efficacy of neoadjuvant polychemotherapy in breast cancer].

A procedure for obtaining microcirculation coefficient is described. It is based on the phenomenon of formation of a focus of radionuclide hyperfixation on scintigrams of tumor area due to embolization of its arterioles and precapillaries with radionuclide. The method was used in 26 breast cancer patients before neoadjuvant chemotherapy. A direct correlation between the microcirculation coefficient and degree of tumor-induced pathomorphosis of tumor cells was established. The coefficient values proved more or less predictive of tumor response to chemotherapy.

Adult↗
PubMed1990

[The fibroepithelial variant of basal-cell skin cancer (Pincus' "premalignant" fibroepithelioma)].

12 cases of the basal cell carcinoma fibroepithelial variant are studied morphologically. This variant of basal cell carcinoma is erroneously diagnosed as adenoid variant of seborrheic keratosis, tubular syringoadenoma or the reverse. Main differential-diagnostic criteria allowing to distinguish a fibroepithelial variant of basal cell carcinoma from an adenoid variant of seborrheic keratosis are multicentric foci of superficial basalioma as well as the absence of hyperkeratosis and intraepithelial carcinomatous cysts. The tumour differs from tubular syringoadenoma by the lack of tubular structures with two-layer epithelial lining and cysts with signs of secretory activity.

Basal Cell Carcinoma↗
PubMed1983

[Epidermoid thymoma--a variety of thymus gland cancer].

Epidermoid thymoma was referred to thymal malignancies after an evaluation of the data on its clinical course and microscopic structure. This tumor may be diagnosed preoperatively on the basis of an analysis of clinico-roentgeno-endoscopic data and findings of a cytological, histological and electron-microscopic examinations.

Adult↗
PubMed1980

[Pathological anatomy of thymus gland tumors].

The paper presents detailed morphological characteristics of 31 thymomas and 25 microscopically similar neoplasias of the anterior mediastinum (carcinoid, seminoma, lymphogranulomatosis, angiofollicular lymphoma, etc). The term "thymoma" is determined as a tumour consisting of two components: mandatory epithelial one and lymphocytes. The diversity of the morphological picture of thymomas is determined mainly by the variability of the epithelial component. The special features of the ultrastructural organization of thymomas (the presence of desmosomes, tonofibrils and basal membrane) were revealed which facilitate the differential diagnosis of the anterior mediastinum tumours.

Carcinoma↗
PubMed1979

[Differential diagnosis of epithelial thymoma and seminoma (histological and electron-microscopic study)].

The paper describes two observations of thymus gland tumours: epithelial thymoma and seminoma. Differential diagnosis of these tumours is very important for the proper selection of the method of treatment as seminoma is more radio-sensitive than epithelial thymoma. Epithelial thymoma is characterized by coarse-fiber stroma, perivascular grouping of cell elements and the lack of glycogen in them. Seminoma consists of light and dark cells containing much glycogen in their cytoplasm. Differences between these tumours are most clearly seen in electron microscopic studies. In epithelial thymoma cells have processes, numerous tonofilaments, desmosomes, and basal membrane. Seminoma cells contain glycogen, no tonofilaments or basal membrane, few desmosomes.

Adult↗
PubMed1979

[Oxygen effect in the therapy of lung cancer].

Nine lung cancer patients were subjected preoperatively to radiotherapy under hypoxia with inhaling of GHM-10 (gas hypoxic mixture). The patients were followed up during 7--12 months. The results obtained evidence the rationality of further studies in this direction, that is of special importance due to introducing of reconstructive--plastic operations on the trachea and bronchi into oncological practice. Thus, there will be a possibility to preserve, in some cases, a porton of the lung. Since the functional status of the lung after surgical and radiation treatment is of primary importance for the duration of patients' survival, the lung tissue protection from side-effects of radiation in irradiating lung tumors may offer good perspectives.

Adenocarcinoma↗
PubMed1979

[Lymphogranulomatosis of the thymus gland ("granulomatous thymoma")].

Thirteen tumors of questionable genesis located in the thymus were studied. The microscopical structure of these tumors was identical to lymphogranulomatosis of other localization. Reactive proliferation of the thymic epithelium and cyst formation are characteristic of lymphogranulomatosis primarily developing in the thymus. The disease was not "granulomatous thymoma" since giant multinuclear cells by their structural characteristics corresponded to reticular elemens and the epithelial component was absent in extrathoracal formations.

Adult↗