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Biomedical subjects

L A Carstens

Publications and source records attributed to L A Carstens.

At least 19 recordsLinked to original sources
PubMed1980

Residual effects of polychlorinated biphenyls on adult nonhuman primates and their offspring.

After 18 mo of consuming a diet containing 2.5 and 5.0 ppm PCB (Aroclor 1248), during which they and their offspring experienced marked alterations in physical status, female rhesus monkeys were placed on a control diet for 1 yr. During this year there was a decided improvement in their general body health and reproductive capabilities. Infants born to these animals were small at birth and during their postnatal life developed signs of PCB intoxication similar to those observed in their siblings born during the period of PCB exposure. These data indicate that the residual effects of low-level ingestion of PCBs by nonhuman primates persist for over 1 yr after discontinuation of exposure. There are also indications that the fetal and neonatal monkeys born to PCB-exposed mothers are more severely affected for a longer period than are the adult female monkeys.

Abnormalities, Drug-Induced↗
PubMed1976

Responses of rats exposed to polychlorinated biphenyls for fifty-two weeks I. Comparison of tissue levels of PCB and biological changes.

Male Sprague-Dawley rats were fed a diet containing mixtures of polychlorinated biphenyls (PCB) isomers (Aroclor 1248, 1254 and 1262) at a concentration of 100 ppm in the diet for 52 weeks. During the subsequent 13 weeks the rats were placed on a control diet. Throughout the course of the experiment the animals ate well, were healthy in appearance and gained weight as rapidly as the control animals. Their hemograms were normal. In spite of the gross normalcy of these animals throughout the 52-week experimental period, clinical and morphologic examinations revealed distinct alterations. There was a decided increase in their total serum lipids and cholesterol and a transient increase in triglycerides accompanied by distinct morphological changes in the liver. Generalized liver hypertrophy and focal areas of hepatocellular degeneration were followed by a wide spectrum of repair processes. The tissue levels of PCB were greater in the animals receiving the higher chlorine mixtures. High levels persisted in these tissues even after the PCBs had been discontinued.

Adipose Tissue↗
PubMed1975

Dehydroretronecine-induced rhabdomyosarcomas in rats.

Two groups of rat were given s.c. injections of either monocrotaline or its major detectable metabolite, dehydroretronecine, biweekly for 1 year. Tissues obtained from partial hepatectomies performed at 4 months on a portion of these animals showed that both compounds caused a decided inhibition of mitotic division in regenerating liver. Rhabdomyosarcomas developed at the site of dehydroretronecine injection in 51.6% of the rats and in 3.3% of the monocrotaline-treated rats. Metastatic lesions were recorded in 8.3% of these animals. In addition to the above, 10% of the monocrotaline-treated rats developed other tumors that included myelogenous leukemias, hepatocellular carcinomas, and pulmonary adenomas. These data indicate that either monocrotaline or its metabolite dehydroretronecine are capable of causing neoplastic transformations in the tissues of experimental animals.

Animals↗