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Biomedical subjects

L A Chernina

Publications and source records attributed to L A Chernina.

5 recordsLinked to original sources
PubMed1979

[Ultrastructural characteristics of soft tissue rhabdomyosarcomas].

Seven rhabdomyosarcomas of human soft tissues were studied electron microscopically. Certain ultrastructural features characteristic of tumour rhabdomyoblasts were revealed: atypical fibrillar apparatus, spatially uneven process of myofibrillogenesis, disturbed cyto- and histotypical differentiation ratio and others. These features may be used for electron microscopic diagnosis of rhabdomyosarcomas among soft tissue tumours of low differentiation.

Adolescent↗
PubMed1976

[The ultrastructure of human rhabdomyosarcomas].

As a result of exploration of the ultrastructure of 5 human rhabdomyosarcomas it was shown that, if present in the cytoplasm, cells of fibrillar bundles consisting of filaments of two types (40-60 A and 100-150 A) and regular aggregations of Z-like bands type present a reliable diagnostic sign of the myogenic origin of tumors. A possibility to determine such undifferentiated microfibrillae in electrone-microscopic study makes it rational to use the method as an adjunct in association with light optics to diagnose malignant soft tissue tumors of occult genesis.

Female↗
PubMed1976

[Fibrillary structures in tumor myoblasts].

An electron microscope study was made of fibrillar structures in various types of cell elements in mice rhabdomyosarcoma. Different stages of myofibril development were followed in such differentiated cell elements as large spindle cells, large round cells and middle spindle cells. In the former two cells, the evolution has riched a stage of bundles of myofibrills with Z-like bands. The highest degree of myofibril maturation occurs in multinuclear myosymplasts. The occurrence of myofibrils being at different stages of evolution within the same cells is characteristic of tumor myoblasts in addition to an excentric unipolarity of cell differentiation and atypical structure of Z-brands. Cytotypical differentiation (myofibrillogenesis in uninuclear cells) may be the case only in those types of rhabdomyosarcoma cell elements which are able to undergo histottypical differentiation (fussion and formation of multinuclear myosymplasts).

Animals↗