Biomedical subjects
Publications and source records attributed to L A Chicherina.
A quantitative method of direct fluometry of the samples without any preliminary extraction of the preparation, devised by the authors helped demonstrate that after its intravenous administration the cyclic antidepressant azaphen rapidly penetrates via the blood-cerebral, blood-ophthalmic, placental and other blood-histological barrier and is then quickly eliminated from the organism.
The toxicology of an original Soviet antidepressant inkasan-3-methyl-8-methoxy-3H, 1,2,5,6-tetrahydropyrazino [1,2,3-ab] beta-carboline hydrochloride was studied in different types of experimental animals (mice, rats, rabbits, dogs). It was established that the drug is less toxic than imipramine. The toxic manifestations (seizures, stereotypy) seen in dogs receiving high doses of inkasan for a long time are likely to be linked with a stimulating component that characterizes the drug action on the central nervous system.
It has been shown in experiments on rats that phenobarbital, hexamidine and benzonal administered in doses producing the induction of liver microsomal enzymes reduce the total toxic action of dioxydin and pathological alterations in the adrenals induced by dioxydin. A possible mechanism of the effect under consideration is discussed.
The toxicity of dioxydin and quinoxidine was studied in experiments on rats and mice given the drugs intravenously. The target organs for both drugs are the adrenals. The pathological process develops in their cortical layer and continues progressing after the drugs are discontinued. Quinoxidine appeared less toxic owing to which the pathological signs in the adrenals were reversible in the majority of animals given this drug in a dose of 100 mg/kg.
The local and resorption action of 50% prospidin ointment administered at doses up to 100 mg/kg for a long time was studied in rabbit experiments. Prospidin ointment was established to exert no resorption action in doses tested. At the site of the ointment application there occur skin necrotic changes. Complete regeneration of the epithelium with hair recovery is recorded 2 months after the drug is discontinued.
An original antibacterial drug dioxidine was subjected to toxicological studies during long-term parenteral administration of 0.5% solution to rats and guinea-pigs (in doses of 25-100 mg/kg). It was found that susceptibility to the drug correlated well with adrenal function. Guinea-pigs were more susceptible to dioxidine than rats. The data obtained indicate the existence of the interplay between non-specific resistance to toxic agents and glucocorticoid potency.