Biomedical subjects

L A Conlay

Publications and source records attributed to L A Conlay.

21 records · Page 2Linked to original sources

PubMed1977

Phenformin and hyperamylasemia in lactic acidosis.

All cases of lactic acidosis occurring during a 23-month period in a metropolitan teaching hospital were reviewed to ascertain the frequency of hyperamylasemia. Serum amylase activity had been measured in 12 of 26 patients and was elevated in eight (67%). Hyperamylasemia was not significantly more frequent in patients with phenformin-associated lactic acidosis than in patients with lactic acidosis who had not received phenformin. Serum amylase activity did not correlate with the severity of acidosis (arterial pH) or with renal function (serum creatinine).

Acidosis↗

PubMed1976

Phenformin and lactic acidosis.

All patients admitted with severe lactic acidosis to a university teaching hospital during a 17-month period were taking phenformin hydrochloride. Serum phenformin concentration was measured in one patient and found to be four to nine times the usual therapeutic concentration. Prerenal azotemia was present at the time of admission in all but one of these patients, but renal function was normal at the time of discharge in those patients with phenformin-associated lactic acidosis who survived. Phenformin-associated lactic acidosis accounted for 7% of the episodes of metabolic acidosis and 27% of deaths due to metabolic acidosis in diabetics.

Acidosis↗

PubMedDate not supplied

[Propofol suppresses sympathetic activity and inhibits the baroreceptor reflex in waking rats].

The effects of propofol on sympathetic nerve activity and on the baroreceptor reflexes were examined in male Wistar rats. Sympathetic nerve activity was recorded directly from a renal nerve electrode placed earlier; baroreceptor reflex activity was estimated by changes in blood pressure (BP) and heart rate (HR) induced by the vasopressor phenylephrine, or the vasodilator, nitroprusside. Awake animals were anesthetized with propofol (10 mg/kg iv bolus, followed by approximately 35 mg/kg/hr by infusion) for 30 min. During the first 3 minutes, propofol increased sympathetic nerve activity by 113%, while mean arterial pressure was lowered to 85% of control. After 20 minutes, both sympathetic nerve activity and blood pressure had declined by 14% below baseline. Heart rate was stable at the level of approximately 110% throughout. Propofol also attenuated the sensitivity of chronotropic and sympathetic components of the baroreceptor reflex (i.e., to 23-43% and 25-34%, respectively). Thus, propofol lowers blood pressure by a central mechanism attenuating sympathetic nerve activity and sensitivity of baroreceptor reflex.

Animals↗