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Biomedical subjects

L A Dourmishev

Publications and source records attributed to L A Dourmishev.

6 recordsLinked to original sources
PubMed1999

Dermatomyositis and drugs.

Dermatomyositis (DM) is an idiopathic inflammatory disorder consisting of skin and skeletal muscle involvement. Patients with skeletal muscle involvement have polymyositis (PM), and those unresponsive to therapy and with characteristic findings on muscle biopsy have inclusion body myositis. Patients without muscle damage and typical skin lesions have amyopathic dermatomyositis. Disease in children (juvenile dermatomyositis) is not associated with malignancy as it may be in adults (paraneoplastic dermatomyositis). Overlap syndrome (OS) is mixed connective tissue disease combining some features of DM, SS and LES. Scleromyositis is overlap syndrome associated with anti-PM-Sci antibodies. Patients with PM, DM or OS with "interstitial lung disease" and anti-synthetase antibodies have an "anti-synthetase syndrome". Various drugs, including d-penicillamine, NSAIDs, anti-infectious agents, as well as lipid lowering drugs, the HMG-CoA reductase inhibitors may cause myopathy and skin lesions (drug induced dermatomyositis). "Dermatomyositis" occurring as adverse reactions of drugs are rare, irregular and impossible to predict in individual patients. They are very interesting in that they may be keys for explaining the pathogenic mechanisms of the disease.

Dermatomyositis↗
PubMed1999

Dermatomyositis associated with malignancy. 12 case reports.

Dermatomyositis (DM) is an idiopathic inflammatory disease of unknown etiology which manifests itself with symmetrical proximal muscle weakness and typical heliotrope skin rash. Internal malignancy is a specific trigger for some cases of DM. The aim of this study is to find predictive signs of cancer in dermatomyositis patients. Twelve (2 males and 10 females) (24%) out of 50 adult patients with DM (10 males and 40 females between 21 and 81 years old) had associated with malignancy (paraneopastic dermatomyositis, PDM). The male: female ratio in patients with idiopathic dermatomyositis (IDM) was 1:3.75 and for PDM it was 1:5. The frequency of dermatomyositis increases with age. PDM is most frequent between 40 and 69 years of life. Associated malignancies were respiratory tract carcinomas in males, genital and breast carcinomas in females. DM preceded the carcinoma in 5 cases (41.7%); 7 patients (58.3%) had already been treated for malignancy. In conclusion PDM in our country is more frequent in females and in the age after 40 years. Association of dermatomyositis with malignancy is relatively high.

Adult↗
PubMed1998

Crusted scabies of the scalp in dermatomyositis patients: three cases treated with oral ivermectin.

BACKGROUND: Cutaneous features in the scalp area among adult patients are rarely considered as a manifestation of scabies. METHODS: Three patients with clinical and laboratory data of dermatomyositis with scalp involvement (fulfill three or four of Bohan and Peter's criteria), of 4 years, 8 months, and 3 years duration, were seen at our department between 1995 and 1996. For relapses of ordinary scabies, they were treated repeatedly with local scabicide with temporary effect. After a symptom-free period during the treatment of dermatomyositis with corticosteroids and azathioprine, they developed diffuse redness with scales and crusts on the scalp areas. Light microscopy examination of material taken from these crusts showed an abundance of live mites. RESULTS: All patients were successfully cured of scabies with a twice oral dose of 200 microg/kg ivermectin within 8 days. CONCLUSIONS: Our patients with crusted scabies of the scalp and dermatomyositis prompted us to change our standard diagnostic and therapeutic regimens. Fascinating features included mimicry of scabies in patients with dermatomyositis, location of parasites on the scalp, suppressed cell-mediated immunity and successful cure of mange by ivermectin.

Adult↗