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Biomedical subjects

L A Dudjak

Publications and source records attributed to L A Dudjak.

10 recordsLinked to original sources

The midlevel practitioner role: one medical center's experience.

Numerous trends in the current health-care environment have converged to produce an increased emphasis on the role of the midlevel practitioner. Financial constraints head the list, including a mandate for the best care at the lowest rates and a resulting shift from costly specialists to primary care providers. The desire to conserve human and technologic resources requires a practitioner with advanced knowledge and skills to serve as gatekeeper in terms of facilitating access to health care, establishing efficient referral patterns, and developing a holistic care plan. The midlevel practitioner also is prepared to facilitate the transition from the intensive care unit to the less costly general care areas. In addition, the inevitable reduction in funds for graduate medical education and the dwindling number of first-year medical students choosing internal medicine as a specialty threaten the ability of academic medical centers in particular to provide adequate housestaff coverage to full-time and voluntary faculty members. Physicians eager to provide efficient, seamless care to patients in the acute care setting, while maintaining an office practice and caseloads at several hospitals, find the support provided by a midlevel practitioner an enhancement to their clinical practice and a solution to the continuous management of acute and chronically ill patients. In this article, the authors describe one medical center's experience in implementing the midlevel practitioner role.

Certification

Cancer metastasis.

Understanding of the process by which tumor cells develop heterogeneity, invade local tissues, and spread to distant tissues is a major goal of cancer research, as it will determine whether clinicians will be able to design more effective therapies for different cancers. Although much has been learned, much remains to be learned. The following summarizes our current knowledge about metastasis: 1. Cancer is the result of transformation of single cells. 2. Transformed cells are less stable and have an increased rate of spontaneous mutation than non-metastatic cells of similar origin. 3. Cells within a tumor are heterogeneous in biological characteristics. 4. The metastatic process is selective for highly malignant cells from within the heterogeneous tumor. 5. The metastatic process is a complex sequence of events with an outcome dependent on both tumor cell and host properties. 6. By the time of diagnosis, many primary solid tumors are biologically heterogeneous and have disseminated to regional or distant sites. 7. By the time of initial diagnosis, metastases in some state of development are thought to exist in approximately 50% of patients. 8. Cancer metastasis is the major cause of treatment failure and mortality in individuals with malignant tumors. The complexity and diversity of human cancer, in conjunction with the complexity and diversity of human beings diagnosed with cancer presents a major challenge to oncology clinicians and researchers.

Humans