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Biomedical subjects

L A Durnov

Publications and source records attributed to L A Durnov.

At least 19 recordsLinked to original sources
PubMed1978

[Electroencephalography in children with malignant neoplasms of the internal organ and support-motor apparatus].

A neurological examination of 120 patients with malignant newgrowths of a different localization and histological structure was conducted. Neurological changes due to lesions of the central and peripheral nervous systems were revealed. With the aid of EEG studies and subsequent clinico-EEG correlations 29 patients were examined. The conclusion is made that EEG studies of malformations in children allow to detect subclinical forms of brain lesions. In most of the cases there was an inadequacy between the slightly expressed cerebral symptomatology and crude changes of the EEG. The changed EEG was especially marked in primary cancer of the liver, also with normalization of the EEG in the development of positive dynamics of the main disease. The studies conducted indicate the significance of EEG in receiving thorough characteristics of the neurological changes in malignant tumors.

Adolescent↗
PubMed1977

[Clinical use of rubomycin in neuroblastoma in children].

The results of treatment of 23 children at the age of 7 months to 11 years suffering from neuroblastoma are presented; 22 patients with tumors, relapses or metastases were subjected to the treatment and 1 child was treated prophylactically after radical operation. Four patients were subjected to roentgen therapy in addition to the treatment with rubomycin. The antibiotic was administered intravenously in doses of 0.7--1.5 mg/kg in 1--3 days or daily. The caurse dose (3--12 mg/kg) was determined by the treatment efficiency and the side reactions. The objective effect was observed in 68 per cent of the patients, including the pronounced objective effect (marks 3 and 2) in 41 per cent of the cases. Leucopenia (less than 4000 cells in 1 mm3 of the blood). thrombocytopenia, vomiting (or nousea) and changes in the ECG were registered in 20 (87 per cent), 4,9 and 2 patients respectively. When the results of the treatment were positive, repeated courses of the therapy within 1.5--2 years were carried out; 18 patients died within 4 months to 2 years after the first course of the treatment with rubomycin because of the disease development. No signs of the disease were observed in 4 children with in 3--6 years of observation.

Child↗
PubMed1976

A study on the relation between the Epstein-Barr virus and some forms of malignant tumors in children.

The presence of antibodies to the virus capsid antigen of the Epstein-Barr virus was established in the sera of children from different forms of neoplasms with the aid of the indirect method of immunofluorescence according to Henle. 69 sera were studied from children with Wilm's tumor, teratoblastoma, reticulosarcoma, neuroblastoma, sarcoma and also from children with benignant tumors. As control served sera from healthy children of corresponding age. As test cells synthesizing the virus capsid antigen the authors utilized a suspension culture of P3HR-I cells, being one of the clones of Burkitt's lymphoma. The performed investigations have shown that in no one group of children with tumor could there be discovered an increase in the content of antibodies to the Epstein-Barr virus in comparison to controls. It has also been revealed that the spread of the Epstein-Barr virus in different groups of patients and healthy children fluctuated between 83 and 100%.

Antibodies, Viral↗