PubMed Health⌕ Search

Biomedical subjects

L A Entsik

Publications and source records attributed to L A Entsik.

4 recordsLinked to original sources
PubMed1983

[Bradykinin, thrombin and prostaglandins as modulators of microthrombogenesis in local injury of the blood vessel wall].

The microthrombogenesis parameters were studied after local laser injury to the rat mesenterial venule in the presence of infusion of bradykinin (20 micrograms/kg/min) and thrombin (10 Units/kg/min). Bradykinin diminished and thrombin, on the contrary, increased the hemostasis parameters, this effect being observed only during the first minutes after the drug infusion. Activation of the blood kallikrein-kinin system preceded the action of thrombin. It is suggested that apart from prostaglandins, the component of the Hageman factor system may play an important role in the control of microhemostasis in the injured vascular wall.

Animals↗
PubMed1981

[Effect of prostaglandins E1, E2, F2 alpha and prostacyclin on the process of local thrombus formation following microvessel wall damage by lasers].

The internal surface of the rat mesentery venule was exposed to laser. Microthrombogenesis was studied from the time of maximal thrombus formation, time of the first embolism occurrence, thrombus area, and rate of embolism formation. Intravenous infusion of PGE1 and prostacyclin led to the reduction of microhemostasis as shown by all the characteristics. PGF2 alpha, on the contrary, exhibited prothrombogenous activity; PGE2 was little effective. Comparison of the active concentrations of the substances administered has demonstrated prostacyclin to have the most powerful action.

Alprostadil↗