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Biomedical subjects

L A Filippova

Publications and source records attributed to L A Filippova.

11 recordsLinked to original sources
PubMed2001

[Ten simultaneous operations in one patient].

In a patient, a woman of 62 years, one surgical team has performed consecutively over 3 h 45 min 10 operations for different diseases: extirpation of the uterus with appendages, removal of retroperitoneal fibrosarcoma, appendectomy, 30 cm-resection of the small intestine, polypectomy from the rectum, creation of sygmorectoanastomosis, plastic reconstruction of postoperative ventral hernia with duplication, sectoral resection of mammary gland, removal of papilloma and lipoma of abdominal wall. The outcome is favorable.

Abdominal Muscles↗
PubMed1995

[Methods for investigation and estimation of individual chemosensitivity of tumors (review)].

A review of the current methods for the estimation of tumor sensitivity to antiblastomic drugs is presented. Methods for the in vitro and in vivo cultivation of tumor cells are discussed. Among them the following methods are reviewed: the method for the cultivation of tumor heterotransplants in diffusion chambers and its various modifications, the method for the cultivation of human tumors under the kidney capsule, the method for the cell cultivation in primary short-term suspensions, the methods using enriched media, the methods for the cell cultivation on acetate cellulose fibres, in monolayers, etc.

Animals↗
PubMed1992

[Cecum gangrene as a complication of amyloidosis in myeloma].

It is a report of a rare case of amyloidosis in myeloma with a predominant localization in the caecum wall with the narrowing of blood vessels and a caecum gangrene and peritonitis as complications. Rarity of the case resulted in an erroneous clinical diagnosis and unjustified appendectomy.

Aged↗
PubMed1975

[Experimental study of the morphogenesis of nutmeg fibrosis of the liver].

Partial structure of the inferior vena cava over the diaphragm carried out experimentally in dogs let to blood stasis in the liver. Biopsy material obtained at different experimental periods demonstrated that fibrosis began to develop from the central and collective veins as a result of proliferation of the fibroblasts of the vein adventitita and "emigration" of the fucsinophilic fibers into the adjacent parenchyma. In parallel there occurred a neoformation of the connective tissue in the areas of hemorrhages and necroses associated with proliferation of the Kupffer's cells. Nutmeg fibrosis proved to have a cellular genesis and as associated with increased tropocollagen activity of fibroblasts.

Animals↗
PubMedDate not supplied

[Granulomatous thymitis with stromal amyloidosis].

In a surgically removed thymus of an 18 year old man granulomatous thymitis with lymphoid follicles, amyloidosis, pseudocysts were observed. Rare occurrence of this pathology, difficulty of the diagnosis, absence of the treatment concept make surgery a method of choice.

Adolescent↗
PubMedDate not supplied

[The individual chemosensitivity of the cells of urogenital tumors in vitro].

Individual chemosensitivity of 20 tumors from oncologic patients was determined by autoradiographic registration of the DNA synthesis inhibition by chemotherapeutics in tumor cells of primary tissue cultures grown in vitro between microscopic slides. Twelve renal carcinomas, 1 renal pelvis carcinoma, 5 urinary bladder carcinomas, 1 testicle teratoblastoma and 1 retroperitoneal space liposarcoma were tested. While the localization and histologic diagnoses were the same the tumors from various patients had strictly different sensitivity to chemotherapeutic drugs. Some tumors were even resistant to all the drugs tested. It was shown that the renal carcinomas had mainly low individual chemosensitivity. In 7 patients stimulation of the DNA synthesis under the action of the chemotherapeutics instead of its inhibition was observed.

Antineoplastic Agents↗