Biomedical subjects
Publications and source records attributed to L A French.
165 college students completed a survey containing a measure of misconceptions about human aggression and attitudinal items on the death penalty from a 1985 Gallup report. Analysis did not provide strong support for the hypothesis that subjects with relatively high numbers of misconceptions about human aggression are more likely than better informed subjects to support the death penalty.
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The incidence, pathogenesis, pathology, clinical presentation, diagnosis, and treatment of metastatic brain tumors are reviewed. The efficacy of the present diagnostic techniques is discussed. The results of brain scanning and/or computerized axial tomography should be confirmed with cerebral angiography to determine as accurately as possible the site and number of metastatic lesions. The treatment of choice at the present time for patients with brain metastases is surgical excision, if the lesion is solitary and is located in an accessible area in a patient who is in good condition. The bases for this choice include palliation of symptoms, prolongation of survival, and identification of a lesion--benign or non-metastatic--which may respond to a specific form of therapy.
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In vitro experiments were performed with a small volume chamber to determine the contractile activity of various vasoactive agents on human basilar and anterior cerebral arteries. Cumulative log-dose response curves were obtained for most of the agents tested including serotonin and three different prostaglandins; many of these curves were found to be similar to curves previously obtained with canine cerebral arteries. It was concluded from these similarities that canine cerebral arteries are a good in vitro model for studying human cerebral arterial spasm. It was also demonstrated that human cerebrospinal fluid, collected up to 17 days after a subarachnoid hemorrhage from patients with clinical and angiographic evidence of cerebral arterial spasm, would cause large, dose-dependent contractions in human anterior cerebral arteries.
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