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Biomedical subjects

L A Ivanova

Publications and source records attributed to L A Ivanova.

At least 19 recordsLinked to original sources
PubMed1996

[Clinical and pathogenetic features of exposure of workers to antimonate ore].

A total of 100 miners exposed to antimonate dust concentrations considerably exceeding the MAC were examined, and 16% of the subjects appeared to have chronic bronchitis. No pneumoconioses were diagnosed. The chronic bronchitis was characterized by mild slow course with I degree of ventilation disturbances. Antimonate ore turned out to induce toxic effects and activate some protective mechanisms: phagocytosis, immune response, inhibition of proteases.

Adult↗
PubMed1996

[Influence of industrial factors on health status of workers engaged in obtaining and processing non-ferrous alloys].

Workers engaged into treatment of nonferrous alloys are exposed to aerosols of condensation and disintegration. Those who contact aerosols of nonferrous metals demonstrate respiratory, gastrointestinal and skin diseases. To reveal a role of occupational factors in formation of those diseases, the authors designed diagnostic criteria according to results of clinical, allergologic, immunologic and cytochemical studies.

Adult↗
PubMed1995

[The prospects for the biochemical monitoring of the genetic effects in human exposure to the hazardous factors of an industrial environment].

Occupational hazards are predominant mutagens in industrial ecology as well as in general ecology. That evidence necessitates studies of genotype regulating homeostasis after exposure to occupational hazards. Such studies could be useful for assessment and forecast of individual risk of occupational diseases, for individual treatment and prophylaxis. That requires through evaluation including detection of DNA defects and reparation, determination of various phenotypes via serum genetic markers showing disease progress and outcome.

DNA↗
PubMed1994

[The chronic action of an alternating magnetic field in murine ontogeny].

Alternating magnetic field induced changes in the blood system both on the level of functioning cell group and on the level of proliferative elements in white mice. The field inhibits the differentiation processes in seminal glands. The field seems to be a biologically active factor exerting its effect in crucial periods of the ontogeny.

Analysis of Variance↗
PubMed1994

[Antioxidants in the combined therapy of patients with chronic destructive pulmonary tuberculosis].

120 patients with chronic destructive pulmonary tuberculosis received etiotropic therapy. 45 patients were given antihypoxant olifen and 45 patients were put on olifen in combination with prednisolone. The rest patients on chemotherapy alone served control. The combination of olifen with prednisolone contributed more actively to discontinuation of bacterial discharge, cavern closing, improvement of blood gas composition and lipid peroxidation.

Adult↗
PubMed1994

[Immunotherapy in the combined treatment of chronic destructive pulmonary tuberculosis].

The paper provides the results of treatment of chronic pulmonary tuberculosis patients by using immunoactive drugs (thymalin and T-activin) and prednisolone, which has been performed by monitoring immunological parameters. The patients with fibrous and cavernous tuberculosis display a combination of antituberculous antibody hyperproduction and specific cell-mediated response inhibition. Immunological hormone therapy allows normalization of the immunological status (an increase in the count and functional activity of T-lymphocytes) and relative stabilization of the process with cessation of bacterial isolation in shorter periods than in the controls, which is favourable to the reduction in hospital treatment periods.

Adjuvants, Immunologic↗
PubMed1994

[The course of pulmonary tuberculosis in adolescents].

The authors summarize data obtained at the examinations of 178 tuberculous adolescents aged 15-17. Primary forms of the disease were diagnosed in 52% of new-onset cases, while infiltrative tuberculosis prevailed among secondary forms (48%). The tuberculosis was detected at prophylactic fluorography in 63.5% of the examinees. Late disease diagnosis was mostly consequent to poor symptoms of tuberculosis.

Adolescent↗
PubMed1993

Clinical significance of HIV DNA in polymorphonuclear neutrophils from patients with HIV infection.

HIV DNA was detected by the polymerase chain reaction technique in polymorphonuclear neutrophils (PMNs) in 11 of 37 (29.7%) HIV-infected patients. A detectable level of HIV DNA in PMNs was more common in symptomatic than asymptomatic HIV infected patients (46.7% and 18.2%, respectively; p < 0.05). HIV DNA in PMNs was detected most frequently in patients with recurrent bacterial pneumonia or Pneumocystis carininii pneumonia. An association between HIV DNA in PMNs and a low CD4/8 ratio as well as high levels of immunoglobulins in the sera was noted. Detectable HIV DNA was found more frequently in patients with neutropenia than in those with a normal level of neutrophils in peripheral blood (44.4% and 28.0%, respectively; p < 0.05). These data suggest that infection of PMNs by HIV may be associated with PMN impairment during HIV infection.

Adult↗
PubMed1991

[Clinical aspects, diagnosis and treatment of various forms of viral encephalitis in children].

The authors provide the clinical and laboratory data on the etiological structure of acute viral encephalitides in children. Special attention is devoted to the description of the clinical picture of the gravest form of encephalitis caused by type I herpes simplex virus. Present the laboratory data on the long-term preservation of type I herpes simplex virus in the CNS, which correlates to the clinical and morphological findings of the subacute or recurrent course of the disease. Discuss the results of the treatment with the antiviral drug acyclovir (zovirax).

Acute Disease↗
PubMed1991

[The effect of tuberculin therapy on immunologic indicators in adolescents with pulmonary tuberculosis].

Study of a combination of immunologic parameters in 29 adolescents with pulmonary tuberculosis who were subject to a combined treatment with the use of tuberculin demonstrated a decline in heightened specific cellular sensitivity, enhancement of antituberculous antibodies synthesis, normalization of the content and functional activity of T- and B-lymphocytes and rise of the level of class G and M immunoglobulins. It has been concluded that tuberculin has a desensitizing action combined with simultaneous stimulation of humoral response and the normalizing action on the T-lymphocyte system.

Adolescent↗
PubMed1991

[The comparative toxicity of inorganic mercury compounds for a cell culture and the whole organism].

In experiments with two tissue culture lines it was shown, that cytotoxicity of mercury (1) derivatives (measured by CL50) is lesser two times, than it was for mercury (2) derivates. No significant differences in cytotoxicity were noted by the cell morphology and monolayer mitosis activity coefficient studies. This demonstrates the equal toxicity and dangerous to both derivates.

Animals↗
PubMed1991

[The health status of workers engaged in the manufacture of inorganic manganese salts].

Workers engaged in the production of inorganic manganese salts revealed lesions of the upper respiratory pathways (catarrhal and subatrophic rhinitis, pharyngitis, laryngitis), skin (contact and allergic dermatitis), cardiovascular disorders. They also showed changes of renal function,mineral metabolism,acid stability of erythrocytes. Activation of the B-system of immunity and allergization of the body are also observed.

Adult↗
PubMed1991

[Working conditions and health status of workers engaged in the production of zinc compounds].

It was established that industrial shops engaged in zinc compounds' processing were characterized by considerable temperature shifts, relative humidity and air motion changes. In drying and packing shops, concentrations of the final product dusts were established at 0.8-2 mg/m3. The major occupational pathology was constituted by skin and upper respiratory tract diseases, including allergic and contact dermatitis, chronic pharyngitis, tonsillitis and rhinitis. Blood tests revealed B-lymphocytes: increases, circulating immune complexes and considerable levels of lymphocytic spontaneous blastotransformations. Erythrocytic acidic hemolysis was markedly changed, which proved disbalances in the system of red blood.

Acetates↗