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Biomedical subjects

L A Konradsen

Publications and source records attributed to L A Konradsen.

6 recordsLinked to original sources

[Atlanto-axial rotation-fixation in a child with clavicular fracture].

A case of an eight-year-old boy who had sustained both a fractured clavicle and rotatory atlanto-axial fixation is described. The last diagnosis was missed for four and a half months. The diagnosis was made in combination with cineroentgenography and computed tomography scanning. Conservative treatment with external traction was first attempted, after which the patient was operated twice with posterior fusion between C-1 and C-2. At six month follow-up the child was without pain, had neutral head holding and about two-thirds of normal rotation.

Atlanto-Axial Joint↗

[Resection of the ulnar head in post-traumatic wrist pain].

In a retrospective study, the effect of distal ulnar resection using the Darrach procedure was evaluated in 42 patients with post-traumatic distal radio-ulnar disability. Thirty women and 12 men, mean age 43 years were seen an average of seven years after the operation. In 57% of the cases the primary trauma was a Colles fracture. The main indication for operation was pain radiating from the distal radio-ulnar joint (83%), but seven patients were without substantial pain. 79% of the patients felt relief of pain after the operation, but 62% still suffered from occasional wrist pain. Twenty-six patients had a supination and a pronation of > or = 150 degrees postoperatively. Thirty-three patients had a dynamic handpower of > 60% of the opposite hand postoperatively. Ten patients stopped working or changed to less physically demanding jobs after the primary trauma. Three patients from this group could after the operation return to their primary physically demanding jobs. Radiographs showed no progress of radiocarpal osteoarthritis during the follow-up period. The Darrach procedure could relieve post-traumatic distal radioulnar pain conditions without adverse effect on radiocarpal function and alignment. Patients who only had mild pain symptoms preoperatively presented unsatisfactory postoperative results.

Adolescent↗

[Arthrosis of the lower limb and running].

In order to assess whether running training for many years predisposes to arthrosis in the lower limbs, the hips, knees and ankle joints of 30 runners who began running training at the beginning of the nineteen fifties were examined. Three of these runners were no longer active. One of these had given up late in the nineteen seventies on account of arthroses in the upper and lower limbs i.e. changes which can scarecely be attributed to the stresses of running. The remaining 27 (90%) had run 20-40 km/week throughout 40 years. Subjective, objective and radiological data were compared with data from 27 non-active control persons who were comparable as regards age, weight/height and occupational stress with the runners. We found no differences in joint mobility, axial deviations or complaints of pain between the two groups. Radiologically, the distances between the osseous joint surfaces in the hip and ankle joints and the degrees of degeneration in the knees were assessed according to Ahlback's classification without any differences being found between the groups. Our results suggest that running training to a moderate extent for many years does not predispose to arthrosis in the lower limbs in healthy individuals.

Adult↗

Thrombin-antithrombin III-complex & fibrin degradation products in plasma: surgery and postoperative deep venous thrombosis.

Thrombin-antithrombin-III complexes (TAT) & D-dimer in plasma, and fibrin(ogen) degradation products (FDP) in serum, were measured in 48 patients subjected to total hip arthroplasty. Blood samples were collected on days -1, 0, 1, 3, 7 and 10. Five patients developed postoperative deep vein thrombosis (DVT) diagnosed by venography. A characteristic pattern of TAT and D-dimer secondary to surgery was demonstrated. A poor correlation was found between ELISA- and latex-D-dimer concentrations after the operation. Patients with DVT had significantly higher TAT-levels preoperatively, and on day 0, 7 and 10. The concentration of FDP was significantly elevated in patients with DVT on day 7 and that of ELISA D-dimer on days 0 & 10. None of the assays are clinically valuable for purposes of postoperative screening for DVT. The preoperative plasma TAT concentration may represent a valuable predictive marker of postoperative DVT.

Adult↗

Dicloxacillin concentrations in amputation.

We treated 18 patients undergoing major lower limb amputation due to ischemia by intravenous administration of 1 g dicloxacillin either 0, 3, or 6 hours before surgery followed by a similar dose 8 hours after the first dose. The administration immediately before the operation resulted in the highest peroperative antibiotic concentrations in the muscular and subcutaneous tissue at the amputation level, exceeding the MIC value of Staphylococcus aureus. Similarly, the concentrations in drain fluid were highest in these patients. The median drain secretion later than 12 hours after surgery amounted to only 5 mL, and at that time the concentration of dicloxacillin was less than the MIC of Staphylococcus aureus in all the samples.

Amputation, Surgical↗