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L A Kupriianova

Publications and source records attributed to L A Kupriianova.

At least 19 recordsLinked to original sources
PubMed2004

[Cytogenetical approaches to the problem of form-formation and subspeciation in the complex Lacerta (Zootoca) vivipara (Lacertidae, Sauria)].

Results of the author's long-term study of the karyotype of Lacerta (Zootoca) vivipara (family Lacertidae, Sauria) have been generalized and supplemented with relevant literature data. Within the species an interpopular karyotype variability was established, and several chromosomal forms were described. Karyotypes of L. (Z.) vivipara from four new, previously not examined populations have been first presented in this paper, and cytogenetical features of their chromosomes are given. Finally, cytogenetical analysis of particular specimens from different localities enabled the author to reveal a new chromosomal form and to define the limits of distribution of other forms of the species. The complex L. (Z.) vivipara has appeared to be more complicated than earlier believed. This complex includes several chromosomal forms of unclear taxonomic status, and some subspecies characterized by various modes of reproduction and distinct distribution ranges. It has been confirmed that in the complex L. (Z.) vivipara intensive chromosomal changes accompany the processes of form-formation and subspeciation. Some cytogenetical regularities of these processes have been demonstrated and compared with hybridogeneous form-formation and speciation. Based on the critical analysis of the available karyological data, some mechanisms of chromosomal changes were described, and their tendencies were determined. In addition, intraspecific relationships were analysed. The proposed scheme was compared with the pattern of intraspecific phylogeny of L. (Z.) vivipara based on molecular data. It has been shown that a high cytogenetical differentiation of the found chromosomal forms and subspecies is correlated with their low morphological differentiation and with a rather low genetical differentiation. The results of the combined analysis suggest the leading role of cytogenetical data for understanding the processes of form-formation and subspeciation. The importance of chromosomal rearrangements in these processes is emphasized, with special reference to their role in the evolution and phylogeny of the complex L. (Z.) vivipara. Some modes of form-formation and subspeciation in this complex are discussed.

Animals↗
PubMed1983

[Morphogenesis of nephrocyte dystrophy].

Morphogenesis of dystrophy of nephrocytes was studied by analysis of 106 biopsies of kidneys from patients with glomerulonephritis using light (semi-thin sections) and electron microscopy. The development of one or another kind of nephrocyte dystrophy was shown to be due to the deficiency of certain mechanisms of renal reabsorption and secretion associated with the corresponding membrane-enzyme systems of the cell. Therefore there is no ground to believe in transition of one kind of nephrocyte dystrophy into another as has been assumed until recently. The point is in the combination of various types of dystrophy (hyalino-drop, hydropic, fatty) within the object under study (biopsy), tubule, or even one nephrocyte. The analysis of the data obtained permits some general conclusions to be made with regard to the morphogenesis and the essence of dystrophy.

Adult↗
PubMed1982

[Focal segmental glomerular hyalinosis: a special form of fibroplastic glomerulonephritis].

Focal segmentary glomerular hyalinosis (FSGH) presenting a picture of glomerulonephritis of the nephrotic type is characterized morphologically. Clinico-morphological criteria for diagnosis are presented. FSGH is characterized by a severe nephrotic syndrome, progressive course, and refractoriness to immunosuppressive therapy, focal and segmentary pattern of changes in the glomeruli, the presence of hyalin masses in some lobules of glomerular capillaries, lipid inclusions in mesangial and endothelial cells, tubular epithelial cells and interstitium, as well as uneven outlines of the endothelial surface of the basal membrane of glomerular capillaries. The diagnosis of early changes in FSGH was shown to require light and electron microscopic and immunohistochemical examinations of kidney biopsies. The problems of the etiology and pathogenesis of FSGH and its independence as a nosological entity are discussed.

Adolescent↗
PubMed1981

[The juxtaglomerular apparatus in chronic glomerulonephritis].

The qualitative and quantitative morphological evaluation of the juxtaglomerular apparatus (JGA) is given on the basis of electron microscopic examinations of JGA in renal biopsies of the patients with mesangio-proliferative and mesangiocapillary glomerulonephritis with or without hypertension. An increase in the total number of JGA cells including granular ones is observed in chronic glomerulonephritis. In hypertensive forms of glomerulonephritis, particularly those with high proteinuria, rhomboidal protogranules were prevalent in the cytoplasm of epithelioid cells, in glomerulonephritis without hypertension and marked proteinuria spheric and lipofuscin-like granules were predominant. In glomerulonephritis with hypertension, an analysis of granule formation in JGA epithelioid cells by formparameter revealed a significant predominance of elongated granules (rhomboidal protogranules), and a lineal correlation analysis demonstrated a strong association between the degree of JGA activation assessed by formparameter values and the duration of the disease. An increase in the number of granulated cells in JGA correlated with the increased activities of glomerular mesangial cells and the appearance of epithelioid cells in the afferent arteriolar wall. The dystrophic changes of adrenergic nerves and their endings developing in glomerulonephritis may be a manifestation of overcharge of nervous apparatuses, particularly in the presence of arterial hypertension.

Adolescent↗
PubMed1980

[Clinical morphological characteristics of intravascular coagulation in glomerulonephritis].

Clinical and morphologic signs of intravascular coagulation have been studied in 63 patients with primary glomerulonephritis (GN) and in 19 patients with nephritis associated with systemic lupus erythematosus. A relationship between the frequency of fibrin deposition in the kidneys and severity of clinical signs and marked morphologic changes in GN has been revealed. Signs of local hypercoagulation are of prognostic significance. A more favourable prognosis is characteristic for patients who show nor fibrin deposition in the renal tissue and whose fibrinolytic system provides an adequate reaction.

Adolescent↗
PubMed1979

[Morphogenesis of immune complex glomerulonephritis].

Morphological changes in the kidneys in nonspecific ulcerative colitis were studied and the following variants of the kidney involvement were established: (1) allergic changes manifested by membraneous and mesangio-proliferative glomerulonephritis, renal vasculitis, phenomena of stromal desorganization with lymphoid and histiocyte infiltrations; (2) metabolic changes manifested by various kinds of degeneration of the tubular apparatus including changes typical of potassium-deficient nephropathy; (3) toxic -- necrotic nephrosis and (4) infectious -- nonsuppurative and suppurative interstitial nephritis.

Glomerulonephritis↗
PubMed1977

[Immunomorphologic criteria of lupoid nephropathy and their value in diagnosing systemic lupus erythematosus].

Immunohistochemical and electron microscopic examinations of 30 kidney bioptates from patients with systemic lupus erythematosus revealed characteristic immunomorphological features of lupoid nephropathy: glomerular immune complexes with the predominance of IgG in combination with other immunoglobulins and fibrin; subendothelial, subepithelial and mesangial depositions in d;fferent combinations found in glomerules; virus-like inclusions in the endothelium of glomerular capillaries. With these signs, the diagnosis of the lupoid nature of nephritis may be established even in those cases where the typical signs of lupus erythematosus are absent or insignificant.

Adolescent↗
PubMed1975

[A clinico-morphologico-functional study of the kidneys in glomerulonephritis].

The article deals with the results of a clinico-functional-morphological study of the kidneys in glomerulonephritis (50 observations) which was carried out with the use of the method of puncture biopsy of the kidneys. It was shown that clinical forms of glomerulonephritis, accompanied with hematuria, were characterized by the absence of fixation of immune complexes in the basal membrane of the glomeruli. According to the electron microscopy data, this corresponds to the dissappearance of deposits from the subendothelial parts of the basal membrane. The extramembranous glomerulonephritis, revealed with the help of electron microscopy technique, was characterized by the nephrotic syndrome. An increased tension of immunological processes in the glomeruli was accompanied by a more grave clinical course of glomerulonephritis, by impairment of not only glomerulous but tubular functions as well. A greater dicrease in the function of osmotic concentration of the urine in fibroplastic types of glomerulonephritis, as compared with non-firboplastic ones, was apparently connected not only with lesiones of tubules but rather with more expressed sclerotic changes in the interstitial tissue of the kidney.

Adolescent↗