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Biomedical subjects

L A Laberko

Publications and source records attributed to L A Laberko.

8 recordsLinked to original sources
PubMed2005

[Individual prognosis of severity of postoperative period and outcome of general peritonitis].

Evaluation of severity according to SAPS scale and examination of dynamics of middle molecules in blood plasma (MCMn) were carried out in 167 patients with different surgical diseases complicated with general peritonitis. It is demonstrated that level of MCMn compared with SAPS scale data is objective index of endotoxicosis, severity of general peritonitis, and it can be regarded as criterion of prognosis of disease outcome. Dynamic assessment of MCMn level has the most diagnostic importance in groups of patients with 5 - 12 scores according to SAPS scale. Prognostic value of this index is small when infectious-toxic shock occurs.

Adolescent↗
PubMed2005

[Results of application of synthetic antioxidants in treatment of patients with destructive pancreatitis].

Results of examination and treatment of 103 patients with pancreonecrosis are presented. Influence of antioxidant mexidol on acute pancreatitis (AP) was studied. It is demonstrated that mexidol in AP permits to slow down destructive processes in the pancreas, promotes localization of inflammation and normalization of clinical and laboratory picture of the disease that permits to decrease significantly number of severe complications of AP and reduce lethality.

Antioxidants↗
PubMed2005

[Extracorporeal detoxication in patients with destructive pancreatitis].

Criteria of severity of endogenous intoxication in patients with destructive pancreatitis in enzymatic toxemia are discussed. It is demonstrated that the level of middle mass molecules and integral index of affection of the pancreas, abdominal cavity and retroperitoneal space are objective criteria of endogenous intoxication and can be used for determination of indications for extracorporeal detoxication and for assessment of treatment efficacy. Prescription of extracorporeal detoxication according to these criteria in an early period of the disease before multiple organ failure development promotes faster management of endotoxemia, prophylaxis of septic complications, decreases lethality and period of treatment of patients with destructive pancreatitis.

Adult↗
PubMed2004

[Correction of enteral insufficiency syndrome in general peritonitis].

Efficacy of enteral ozone lavage in combined treatment of patients with general peritonitis is analyzed. It is demonstrated that intestinal lavage with ozone-enriched physiological salt solution through nasointestinal probe in postoperative period eliminates effectively bacterial contamination of the intestine, decreases toxicity of enteral contents and leads to significant improvement of functional characteristics of the small intestine and results of treatment.

Enterosorption↗
PubMed1999

[Sanative postoperative laparoscopy using rapid bacteriological methods in comprehensive treatment of patients with diffuse peritonitis].

In treatment of patients with diffuse peritonitis the authors have been using postoperative sanative laparoscopy which proved to provide a means not only for rapid evaluating the dynamics of peritonitis course, but also for carrying out a series of therapeutic manipulations aimed at proper management of infections and inflammatory complications. Sanative laparoscopy was accompanied by taking samples of peritoneal exudate to study sensitivity of microflora to antibiotics and antiseptic substances, ensuring rational antibacterial treatment of peritonitis. This therapeutic method was used in 38 patients who underwent 60 examinations. Sanative laparoscopy was of a planned character in 30 patients, and in 8 cases it was carried out for emergency indications. All the studies were performed within 12-23 hours. A single examination was carried on in 11 subjects, the rest of the patients demanding from 2 to 3 examinations. No complications related to sanative laparoscopy were observed. Positive outcome was noted in the majority of the patients, re-laparoscopy being indicated but for 3 patients. Two patients died due to causes not related to the pathology involved.

Anti-Bacterial Agents↗
PubMed1989

[A rapid test of urine microflora sensitivity to antibacterial drugs in the treatment of children with nonspecific inflammatory diseases of the kidney and urinary tract].

The authors describe their own method for rapid determination of urine microflora sensitivity to antibacterial drugs. The method is based on the capacity of the microorganisms (as a totality of particles with the refractive index different from that of the medium) of increasing the optical density of the medium under the conditions of unlimited resources of the nutrition and space at the expense of reproduction in a liquid culture medium. The lack of the optical density increase in the urine sample after addition to it of a certain amount of antibacterial substances evidences the death of the population of the microorganisms and of its sensitivity to the antibacterial drug under study. The method proposed by the authors was compared to those widely used in clinical practice. With special reference to a concrete patient, the results obtained with the authors' method turned out to correlate with those derived with the use of the conventional methods for urine microflora sensitivity to antibacterial drugs (the disc method and the triphenyltetrazolium chloride test). That the final result of the investigation can be obtained after 2--6 hours and low labour intensivity of the method permit the institution of adequate antibiotic therapy within the first day since the patient's admission to the hospital.

Anti-Bacterial Agents↗
PubMedDate not supplied

[A method of determining the sensitivity of urinary microflora to antibacterial drugs].

A method has been developed for speedy determination of urinary microflora sensitivity to antibacterial drugs, which differs from other existing techniques by its simplicity and rapid realization. It is based on the capacity of micro-organisms as an aggregate of particles with a refraction coefficient, different from that of the environment, to increase its optic density by multiplication in a liquid nutrient medium in conditions of unlimited nutrition and space. Thus, increased optic density of a urinary specimen with an added antibacterial agent during incubation in a thermostat would indicate an increased count of micro-organism in the medium, i.e. the lack of sensitivity to the antibiotic in question. Optic density being unchanged under such conditions is evidence of the death (lack of growth) of the micro-organism population and, hence, its sensitivity to the anti-bacterial drug being assessed. The ultimate results being obtainable within 2 to 6 hrs and little effort involved are the advantages of this method over conventional techniques of the determination of urinary flora sensitivity to antibacterial drugs that are in current clinical use. Besides, adequate antibacterial treatment can already be initiated within the first day of admission where this test is used.

Anti-Infective Agents, Urinary↗